Neurosearch A/s

Ge Healthcare As

Amersham Health As

Meiji Seika Kaisha, Ltd.

Nycomed Imaging As

Nerosearch A/s

General Electric Company

Oskar Axelsson

Dan Peters

Stefan Petersson

Klaes Golman

Georg Hansson

Ib Leunbach

Peter Moldt

Lars-Goran Wistrand

Jan Henrik Ardenkjaer-Larsen

Haukur Johannesson

Lene Teuber

Frank Watjen

Robert Edgar Colborn

Palle Christophersen

Mikkel Jacob Thaning

Andrew Soliz Torres

Elsebet Ostergaard Nielsen

Jan-Henrik Ardenkjaer-Larsen

Axel Morgenstjerne

Harry John Wadsworth

Jorgen Drejer

Paul William Buckley

Ian M Newington

Brian Christopher Bales

Charlotte Olofsson

Jorgen Scheel-Kruger

Haukur Johanneson

Sven Goran Andersson

Duncan George Wynn

Dennis O'Shea

Amit Mohan Kulkarni

Mikkel Thaning

Andreas Olsson

Sven Mansson

Nicolas Lasbistes

Robert James Domett Nairne

Frank W Atjen

Sven Månsson

Lars-Göran Wistrand

Jan Henrik Ardenkj&aelig;r-Larson

Lars-G&ouml;ran Wistrand

Bjarne Hugo Dahl

Nielsen Elsebet Stergaard

David Demoulpied

Jr Peter Bonitatibus

Duncan Wynn

Sven Andersson

The present invention relates to chelators, in particular to chelators which are capable of forming complexes, i.e. paramagnetic chelates, with paramagnetic metal ions. The invention also relates to said paramagnetic chelates, said paramagnetic chelates linked to other molecules and their use as contrast agents in magnetic resonance imaging (MRI).

Paramagnetic chelates thereof and their use as contrast agents in magnetic resonance imaging (MRI)

The invention relates to an improved process for preparation of protected DO3A, such as DO3A-tri-t-butyl ester (1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid tri-t-butyl ester). The compound is prepared as a salt. The process includes a work-up procedure giving DO3A-tri-t-butyl ester as a salt of excellent purity.

Synthesis of cyclen derivatives

The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing an aliphatic central moiety containing amide functions allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.

Contrast agents

The present invention relates to iodine containing compounds containing a central cyclopropane scaffolding moiety allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.

The present invention provides a process for the preparation of an MR contrast agent, said process comprising:

Process for preparation of MR contrast agents

The present invention provides a method of contrast enhanced magnetic resonance imaging of a sample, said method comprising: a) administering a hyperpolarised MR contrast agent comprising non-zero nuclear spin nuclei into said sample for fluid dynamic investigations of the vasculature, b) exposing said sample or part of the sample to radiation of a frequency selected to excite nuclear spin transitions in said non-zero nuclear spin nuclei, c) detecting MR signals from said sample using any suitable manipulation method including pulse sequences. The invention also provides novel compounds.

Method of magnetic resonance investigation of a sample using a nuclear spin polarised MR imaging agent

The present invention provides a method of MR investigation of a sample, said method comprising: (i) nuclear spin polarizing a high T1 MR imaging agent which contains in its molecular structure at least two hyperpolarisable nuclei within the same molecule, the frequency difference between the two resonance lines from said nuclei, &#x3b4;&#x3c5;, being dependent upon either the temperature or the pH of said sample; (ii) administering the nuclear spin polarized MR imaging agent to said sample; (iii) exposing said sample to a radiation at a frequency selected to excite nuclear spin transitions in said MR imaging agent; and (iv) detecting and manipulating magnetic resonance signals from said sample using a single-shot RARE acquisition sequence with shifted data acquisition.

MR-method for the in vivo measurement of temperature or pH-value by means of a hyperpolarised contrast agent

A method of magnetic resonance investigation of a sample by (i) reacting ortho-deuterium enriched hydrogen with a hydrogenatable MR imaging agent precursor to produce a hydrogenated (i.e. deuterated) MR imaging agent; (ii) optionally, subjecting the hydrogenated MR imaging agent to a low magnetic field;(iii) administering the hydrogenated MR imaging agent to the sample; (iv) exposing the sample to radiation of a frequency selected to excite nuclear spin transitions of selected non-zero nuclear spin nuclei in said hydrogenated MR imaging agent; (v) detecting magnetic resonance signals of the selected non-zero nuclear spin nuclei from the sample; and (vi) optionally, generating an image or biological functional data or dynamic flow data from the detected signals.

Magnetic resonance imaging

The invention provides a method of magnetic resonance investigation of a sample, said method comprising: (i) reacting para-hydrogen enriched hydrogen with a hydrogenatable MR imaging agent precursor containing a non-hydrogen non-zero nuclear spin nucleus to produce a hydrogenated MR imaging agent; (ii) administering said hydrogenated MR imaging agent to said sample; (iii) exposing said sample to radiation of a frequency selected to excite nuclear spin transitions of said non-zero nuclear spin nucleus in said hydrogenated MR imaging agent; (v) detecting magnetic resonance signals of said non-zero nuclear spin nucleus from said sample; and (vi) optionally, generating an image or biological functional data or dynamic flow data from said detected signals.

Para-hydrogen labelled agents and their use in magnetic resonance imaging

The present invention relates to compounds of formula (I), any of it enantiomers, or any mixture thereof, or a pharmaceutically acceptable acid addition salt thereof, wherein R , R , R , R , R , R , R , R and R each independently are hydrogen, alkyl, alkoxy, halogen, trifluoromethyl, nitro, cyano, amino, acyl, alkylamino, dialkylamino, aminocarbonyl, or acylamino; R5 is hydrogen, alkyl, alkoxyalkyl, or phenylalkyl; X is &mdash;CH &mdash;Z&mdash;, Z&mdash;CH &mdash;, NH&mdash;CO&mdash;, &mdash;CO&mdash;NH&mdash;, or &mdash;CH&boxH;CH&mdash;; wherein Z is O, S, CH , or NH; Y is O, &mdash;CH &mdash;W&mdash;, &mdash;W&mdash;CH &mdash;; wherein W is O, or S; and n is 0, 1 or 2. The compounds are useful in the treatment of psychotic disorders.

Disubstituted morpholine, oxazepine or thiazepine derivatives, their preparation and their use as dopamine d4 receptor antagonists

The present invention provides a method of magnetic resonance investigation of a sample, preferably of a human or non-human animal body. The method comprises the step of ex vivo polarization of a high T agent. The polarizing agent is optionally separated from the high T agent before the high T agent is administered to the sample.

Method of magnetic resonance investigation

The invention relates to a method of magnetic imaging (MR) of a living sample comprising the steps of hyperpolarizing a hyperpolarizable gas ex-vivo and transferring the nuclear polarization from the hyperpolarized gas to the nuclei of an MR imaging agent, that is not hyperpolarizable, that is exposed to a uniform magnetic field and that is introduced in contact to the hyperpolarizable gas, separating the hyperpolarizable gas from the MR imaging agent, administering the MR imaging agent to the living sample, exciting NMR transitions in the nuclei of the imaging agent and detecting an NMR signal thereof.

Method of magnetic resonance imaging

The present invention provides a method of magnetic resonance investigation of a sample, preferably of a human or non-human animal body, said method comprising the step of ex vivo polarisation of a high T,agent and wherein the polarising agent is optionally seperated from the high T,agent before the high T,agent is administered to the sample.

Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent

The present invention relates to compounds of formula (I), any of it enantiomers, or any mixture thereof, or a pharmaceutically acceptable acid addition salt thereof, wherein R,, R,, R,, R,, R,, R,, R,, R,and R,each independently are hydrogen, alkyl, alkoxy, halogen, trifluoromethyl, nitro, cyano, amino, acyl, alkylamino, dialkylamino, aminocarbonyl, or acylamino; R5 is hydrogen, alkyl, alkoxyalkyl, or phenylalkyl; X is &mdash;CH,&mdash;Z&mdash;, Z&mdash;CH,&mdash;, NH&mdash;CO&mdash;, &mdash;CO&mdash;NH&mdash;, or &mdash;CH&boxH;CH&mdash;; wherein Z is O, S, CH,, or NH; Y is O, &mdash;CH,&mdash;W&mdash;, &mdash;W&mdash;CH,&mdash;; wherein W is O, or S; and n is 0, 1 or 2. The compounds are useful in the treatment of psychotic disorders.

Disubstituted morpholine, oxazepine or thiazepine derivatives, their preparation and their use as dopamine D4 receptor antagonists

Growing community of inventors

Malmo, Sweden

Oskar Axelsson