Temple University

Oscar Mauricio Perez Leal

Salim Merali

Carlos A Barrero

Steven G Kelsen

Camilo Moncada

Magid A Abou-Gharbia

Wayne Everett Childers

Provided is a method for diagnosing and/or staging COPD based on detection of one or more histone proteins. In some embodiments, the histone protein is an H3.3 protein comprising a post-translational modification. In some embodiments, the histone protein is H2B, H3, H3.3 or H4. Kits for practicing the methods of diagnosis and/or staging are provided as well. Further provided is a method for treating COPD.

Diagnosis and treatment of chronic obstructive pulmonary disease (COPD) based on elevated levels of extracellular H3 protein

The invention provides an isolated nucleic acid having a sequence encoding a spermidine/spermine acetyltransferase ('SSAT'), wherein translation of an mRNA comprising the encoded SSAT has increased basal translation and increased stimulated translation, compared to a wild-type mRNA encoding SSAT. Methods of use for the nucleic acid are also provided. Methods and compositions are also provided for reducing ischemia-reperfusion injury in organs or tissue for transplantation.

SSAT mRNA translation repression and activation

Diagnosis and treatment of chronic obstructive pulmonary disease (COPD)

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Barranquilla, Colombia

Oscar Mauricio Perez Leal