Mitsui Toatsu Chemicals, Incorporated

Osamu Yano

Nobuyuki Fukazawa

Hajime Iizuka

Yukio Miyama

Hiroshi Yamamoto

Kengo Otsuka

Takafumi Kitano

Yoshio Furutani

Daiji Iwata

Tamotsu Fukuda

Shizuo Shimada

Tuneji Suzuki

Yukichi Kawai

Compounds having an activity to stimulate the carcinostatic effect of carcinostatic agents, which can be expressed by the following general formula (1): ##STR1## in which A is ##STR2## (in which R.sub.1, R.sub.2 and R.sub.3 are each independent and represent a hydrogen atom or a phenyl group) are made into fumarates so as to improve their oral absorbability and solubility in water without interfering with their effects.

Quinoline derivative fumarates

Amide derivatives of dihydrocaffeic acid and their application to

Dihydrocaffeic acid derivatives are here disclosed which are applicable as medicines having excellent absorbency in the case of oral administration and good concentration retention in blood. The disclosed compounds have the function to induce the production and secretion of a nerve growth factor (NGF) in the brain tissue, and therefore they are effective as medicines for the progression inhibition and therapy of regressive disorders of the central nervous system.

Dihydrocaffeic acid derivatives and pharmaceutical preparation

Dihydrocaffeic acid derivatives and pharmaceutical preparations

DNAs, the salts thereof, the mixtures of DNA and RNA in which the DNA is mostly contained, and the mixtures of the salt of DNA and the salt of RNA in which the salt of DNA is mostly contained are used as active ingredients for pharmaceutical preparations for digestive ulcer, for example, DNA and RNA being obtained from BCG.

Method for the treatment of digestive ulcers

Thermally-denatured DNA MD-011 having an antitumor activity was obtained by heating the substance separated from the disrupted cells of bacteria belonging to genus Mycobacterium.

Thermally-denatured deoxyribonucleic acid MD-011 and antitumor agent

Growing community of inventors

Mobara, Japan

Osamu Yano