Matsushita Electric Works, Ltd.

Other

Fuso Pharmaceutical Industries, Ltd.

Tohoku University

Minolta Camera Kabushiki Kaisha

Sumitomo Electric Industries, Limited

Gunma University

Osu Corporation

Junsei Educational Institution

I. Sumitomo Electric Industries, Ltd.

Osamu Yamada

Toshiyuki Masuda

Jing Zhang

Yoshiteru Oshima

Haruhisa Kikuchi

Mitsunobu Kuroda

Shinya Kida

Toshio Hattori

Mitsue Koizumi

Yoshinari Miyamoto

Toshiaki Tokizane

Yoshiharu Ito

Akira Yamakawa

Osamu Komura

Eiji Kamijo

Masayuki Mino

Masaaki Honda

Yuzuru Kubohara

Shinya Murase

Yoshihisa Matsushita

Masayuki Kanaya

Hiroshi Yoshida

Ichiro Matsubara

Hitoshi Kageyama

Motoharu Terada

Shinichi Mori

Hiroshi Yamashita

Osamu Iijima

Susumu Nakano

Junpei Maruo

Manshi Ooyanagi

Kimiaki Tanihata

Akihiko Hamada

The present invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R, R, m and n are as defined in the specification, with an inhibitory effect of PD-L1 expression and an inhibitory effect of reduced production of IL-2 and a medicament useful for the treatment of a disease associated with the reduced immune function caused by the formation of PD-1/PD-L1 binding.

Compound having PD-L1 expression-suppressing action

The present invention provides a useful medicament for the treatment and/or prophylaxis of a disease associated with the enhancement of OPN production including cancer, which comprises a compound of formula: wherein R, R, R, R, R, R, R, m, n, p, X, and Y are as defined in the specification, a pharmaceutically acceptable salt thereof.

Amide derivative

The present invention provides a medicament useful for treatment and/or prevention of cancer, a vaccine adjuvant, and an inhibitor of immune checkpoint comprising a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein Bonds a-d, Ring A, R, R, R, R, R-R, and n are as defined in the present specification.

Indole alkaloid compound having immune checkpoint inhibitory action

Disclosed are a pharmaceutical composition, cosmetic product, and food or drink product each comprising a porous ceramic obtained by combustion synthesis of a starting material comprising (1) titanium and (2) at least one member selected from the group consisting of carbon, boron, nitrogen, and silicon; a pharmaceutical composition and cosmetic product each comprising a radical- and nanobubble-containing liquid; and a blood treatment device comprising a blood flow channel for extracorporeal circulation of a patient's blood, the blood flow channel being provided with the porous ceramic above, and the porous ceramic and the blood are brought into contact with each other.

Medicinal composition, blood treatment device, cosmetic, food and drink using combustion synthesis material

Disclosed herein is an osteopontin production inhibitor capable of preventing a disease resulting from increased production of osteopontin. The osteopontin production inhibitor contains a dictyopyrone derivative or a dihydrodictyopyrone derivative as an active ingredient. The dictyopyrone derivative is preferably a compound represented by Chemical Formula 1 or 2, and the dihydrodictyopyrone derivative is preferably a compound represented by Chemical Formula 3 or 4.

Osteopontin production inhibitor containing dictyopyrone derivative or dihydrodictyopyrone derivative as active ingredient

The present invention provides a method for efficiently producing an intermetallic compound porous material. Specifically, the invention provides a porous material production method comprising molding a mixed powder of at least two inorganic powders and performing a combustion synthesis reaction of the resulting molded mixed powder; wherein (1) the porous material contains an intermetallic compound, (2) the intermetallic compound has a three-dimensional network skeletal structure, and (3) the porous material has a relative density of not more than about 80%.

Method for producing intermetallic compound porous material

Nucleic acid sequences for enhancing expression of a useful gene, which car increase the production of the gene product by enhancing gene expression, comprising a 5'-untranslated region of a viral gene or a fragment or a variant thereof, vectors comprising the nucleic acid sequence, host cells transformed or transfected with the vector, and methods for enhancing expression of a useful gene with the vector are provided. In addition, the sequences of the present invention can be utilized for screening an agent that interacts with IRES elements, and of an IRES-dependent translation initiator, as well as for treating diseases resulting from reduction of cap-dependent mRNA translation or reduction of IRES activity, and for determining severity of hepatitis C.

Nucleic acid sequence for potentiating the expression of useful gene and method therefor

A data setting system for terminal units using an optical wireless signal includes in the respective terminal units a data storing device and a receiving device for the optical wireless signal and, in a data operating device separate from the terminal units, an operating device for preparing and transmitting a setting signal to the terminal units. The setting of data in the respective terminal units employed in a remote supervisory and controlling system using a multiplex data transmission is thereby possible from a remote position from the terminal units through the optical wireless signal.

Data setting system for terminal units in remote supervisory and

An apparatus for editing color image capable, by having a desired color in an original designated and an editing mode selected, of image editing for an image in the designated color in such an editing mode as trimming, masking, erasing, and conversion to another color. A desired color in an original image is designated by a designated color input portion and thereby designated color data for separated colors are obtained. Thereafter, the original image is scanned and image data for separated colors are obtained. The thus input image data are electrically edited in the selected edit mode based on the designated color data and the edited image data are output to an image forming unit and thereby an edited color image is obtained.

Image forming apparatus capable of editing color image

A remote supervisory and controlling System for remotely supervising and controlling loads in time-divisional multiplex transmission of control and monitor data between a central control and terminal units each connected to the central control unit through a two-wire line. Supervision and control of the overall system can be carried out from a plurality of locations so that failure of a central or host computer will not render the overall system inoperative.

Remote supervisory and controlling system

Process for preparing NbN superconducting material, characterized in that a bulk Nb is placed in powder including at least one metal which can be nitriding-burned, and then the powder is heated to be nitriding-burned in pressurized N.sub.2 atmosphere so that the bulk Nb is nitrided by the nitriding-burning of the powder.

Process for preparing NbN superconducting material

A remote supervisory and controlling system for remotely supervising and controlling loads in time-divisional multiplex transmission of control units and monitor data between a central control and terminal units each connected to the central control unit through a two-wire line. Supervision and control of the overall system can be carried out from a plurality of locations so that failure of a central or host computer will not render the overall system inoperative.

A remote supervisory and controlling system for remotely supervising and controlling loads in time-divisional multiplex transmission of control unit and monitor data between a central control and terminal units each connected to the central control unit through a two-wire line. Supervision and control of the overall system can be carried out from a plurality of locations so that failure of a central or host computer will not render the overall system inoperative.

Remote supervisory and controlling machine

There is disclosed an electrophotographic printer for projecting light from light source emitted according to image data onto a photoconductive body performing a mechanical scan operation in a subscan direction so as to form an image of the image data thereon, and for printing the image on a piece of printing paper using the electrophotographic process. In the electrophotographic printer, the light source comprises plural light emitting devices such as LEDs aligned in a main scan direction perpendicular to the subscan direction, and each light emitting device has a light output opening elongated in the subscan direction. Image data received from an external unit are once stored in an image memory, and the image data read therefrom are Fourier transformed. Thereafter, the Fourier transformed data are multiplied by a predetermined frequency characteristic defined by the shape of each light output opening, and data of the obtained product are Fourier inverse transformed as the image data to be printed, thereby improving a deterioration of the quality of said printed image caused when said light output opening is used.

Electrophotographic printer comprising aligned plural light emitting

The present invention relates to a method of sintering ceramics and ceramics obtained by said method. According to the present invention, the synthesis and sintering of ceramics can be simultaneously carried out by utilizing the reaction heat generated when at least one metallic element selected from metallic elements of IIb, IVb, Vb and VIb groups of the Periodic Table is combined with at least one nonmetallic element such as B, C N and Si without heat or by preliminarily heating the ceramics at temperatures remarkably lower than the usual sintering temperature ceramics thus-produced are superior in abrasion resistance and corrosion resistance. Furthermore, according to the present invention, particles of the same kind of metal as that used in constructing the ceramics comprising the above described metallic elements and nonmetallic elements are dispersed in a matric comprising said ceramics to obtain metal dispersed reinforced ceramics in which both the matrix and the metallic particles are strongly and chemically bonded to each other. According to the latter procedure, ceramic materials having high temperature characteristics, high corrosion resistance and high abrasion resistance, as well as high toughness and high impact resistance can be obtained.

Growing community of inventors

Osaka, Japan

Osamu Yamada