Takara Shuzo Co., Inc.

Nippon Shinyaku Company, Ltd.

Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai

Osamu Tanabe

Akira Obayashi

Hamao Umezawa

Teruya Nakamura

Hironobu Iinuma

Tsutomu Taniguchi

Kazuo Nakajima

Osamu Suzuka

Masao Murayama

Yoshiaki Hirata

Hiroyuki Uchida

Hiromu Murai

Shingo Matsumura

Masaji Ohno

Hirokazu Kotani

Takuma Sasaki

Toshinori Miyabe

Tomoko Shiomi

Yoshie Kimizuka

Akiro Obayashi

The invention relates to a high molecular weight .beta.-1,3-glucan composed of repeated glucopyranose units, each unit being represented by the formula: ##STR1## The .beta.-1,3-glucan exhibits anticarcinogenic activity. A process for producing said glucan is also claimed.

Polysaccharides having anticarcinogenic activity and method for

The present invention provides a process for preparing a optically active .beta.-(S)-aminoglutaric acid monoalkyl ester of the formula: ##STR1## wherein R is a lower alkyl group having 1 to 4 carbon atoms, which comprises subjecting a .beta.-N-protected aminoglutaric acid dialkyl ester of the formula: ##STR2## wherein each R is as defined above and A is an easily removable protecting group, to an action of an enzyme produced by a microorganism belonging to the genera Flavobacterium, Achromobacter, Xanthomonas, Alcaligenes, Serratia, Gluconobacter, Chromobacterium and Acetobacter, to selectively hydrolyze only one of the two ester groups, and then removing the protecting group.

Method of preparing optically active .beta.-(S)-aminoglutaric acid

A polysaccharide having anticarcinogenic activity, and a process for its production from a strain of the genus Isaria of the class Hyphomycetes.

5-Benzy-2-pyridine carboxylic acids, in which the benzyl group is optionally substituted by one or two like or different alkyl, halo, alkoxy, nitro, amino, acetamido, hydroxy or acetoxy groups, and the corresponding amides and esters, possess dopamine .beta.-hydroxylase inhibitory properties and are useful as blood pressure lowering agents. The compounds, of which 5-(4-chlorobenzyl)-2-pyridine carboxylic acid, 5-(4-hydroxybenzyl)-2-pyridine carboxylic acid and 5-benzyl-2-pyridine carboxylic acid are typical examples, can be prepared by a number of chemical methods.

5-Benzylpicolinic acid derivatives

There is disclosed a new antibiotic called calvatic acid having the structure p-carboxyphenyl-azoxycarbonitrile and processes for its production by fermentation and processes for its recovery and purification. This substance is effective in inhibiting the growth of Gram-positive bacteria and carcinoma.

P-carboxyphenyl-azoxycarbonitrile and its methyl ester

Phenopicolinic acid is produced by culturing a strain of Paecilomyces. The compound, which may be alternatively named as 5-(4-hydroxybenzyl)-2-pyridinecarboxylic acid, is a hypotensive agent.

Process for the preparation of phenopicolinic acid

Production of a new antibiotic, calvatic acid

Growing community of inventors

Uji, Japan

Osamu Tanabe