Schering Aktiengesellschaft

Bayer Schering Pharma Ag

Mitsui Chemicals, Inc.

Bayer Pharma Aktiengesellschaft

Osamu Nakanishi

Tsuneji Suzuki

Tomoyuki Ando

Katsutoshi Tsuchiya

Eishi Tanaka

Yoshinori Shiraishi

Akiko Saito

Takashi Yamashita

Tsuchiya Katsutoshi

A method of treating a malignant tumor selected from the group consisting of leukemia, colorectal cancer, ovarian cancer, oral cancer, lung carcinoma, breast carcinoma, prostate carcinoma, and melanoma by administering to a patient in need thereof an effective amount of at least one compound represented by formula (1) wherein A, X, Q, R, and n are defined herein.

Cell differentiation inducer

The novel benzamide derivative represented by formula (1) and the novel anilide derivative represented by formula (13) of this invention has differentiation-inducing effect, and are, therefore, useful a therapeutic or improving agent for malignant tumors, autoimmune diseases, dermatologic diseases and parasitism. In particular, they are highly effective as an anticancer drug, specifically to a hematologic malignancy and a solid carcinoma. 

Cell differentiation inducer, benzamide compounds

Benzamide derivatives and pharmaceutical compositions containing same

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Pasadena, CA, United States of America

Osamu Nakanishi