Agency of Industrial Science and Technology

Ministry of International Trade & Industry

National Institute of Advanced Industrial Science and Technology

Agency of Industrial Science and Technology Ministry of International

Osamu Nakamura

Isao Ogino

Teruo Kodama

Hiroyuki Kageyama

Mitsuharu Tabuchi

Hideki Ohba

Seiji Yasuda

Kazuaki Ado

Imre Sallay

Fumio Yagi

Sawako Moriwaki

Tomonari Takeuchi

Yoshizo Miyake

Masakazu Adachi

Shunichi Higuchi

Yoko Fuke

Susumu Okazaki

Sachio Takahashi

Elisabeth Betourne

Yuria Saito

Yoshifumi Yamamoto

An efficient method for therapeutic treatment of a leukemic patient is disclosed in which the patient's body fluid under external circulation is brought into direct contact with an adsorbent material capable of adsorbing the leukemic cells in the body fluid specifically and selectively. The leukemic cell-adsorbent material, which is used by filling a column to form an adsorbent bed, is a conjugate of a lectin protein extracted from, e.g.,beans or soybeans coupled with a physiologically inert carrier material such as a polysaccharide in the form of beads or a superparamagnetic material in the form of iron oxide-based magnetic beads.

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Disclosed is a method for growth inhibition of human leukemic cells or therapeutic treatment method of a leukemic patient by using a medicament of which the effective ingredient is a methylsulfinylalkyl isothiocyanate such as 4-(methylsulfinyl)butyl isothiocyanate and 6-(methylsulfinyl)hexyl isothiocyanate, which can be prepared by extraction from the tissues of certain plants and can induce apoptosis in human leukemic cells. This medicament compound is little growth-inhibitive against normal cells as compared with leukemic cells, so that a remarkable therapeutic effect can be expected.

Leukemic cell growth inhibiting method

An efficient method for therapeutic treatment of leukemia is provided in which a patient's body fluid during external circulation is brought into direct contact with an adsorbent material capable of specifically and selectively adsorbing leukemic cells in the body fluid. The leukemic cell-adsorbing material is a composite of a lectin protein coupled with a physiologically inert carrier material such as a galactan polysaccharide in the form of beads. The lectin protein may be obtained from a mushroom fungus such as or a leguminous seed such as from the jequirity bean plant. The lectin protein and carrier material can be bound by forming chemical linkages between amino groups in the lectin protein and functional groups in the carrier material, and unreacted functional groups of the carrier material may be blocked with an amino acid. A leukemic cell-adsorbing column may be formed by filling the leukemic cell-adsorbing material into a tubular body to form an adsorbent bed. The tubular body may have an inner diameter of from 10 to 20 mm and a height of from 50 to 200 mm.

Leukemic cell-adsorbing material containing lectin protein from Agrocybe cylindracea or jequirity plant seed

A high sodium ion conducting inorganic composite solid electrolyte obtained by mixing Na.sub.4 Zr.sub.2 Si.sub.3 O.sub.12 with titanium oxide and sintering the resultant mixture and a method for the production of a high sodium ion conducting inorganic composite solid electrolyte, consisting essentially of the steps of mixing Na.sub.4 Zr.sub.2 Si.sub.3 O.sub.12 with titanium oxide and sintering the resultant mixture.

High sodium ion conducting inorganic composite solid electrolyte and

A method of determining the charge and/or discharge capacities of non-aqueous batteries with an operating voltage of about 4 volts, is provided including determining an inverse molar susceptibility value at each of a plurality of different temperatures for a plurality of lithium manganese spinel oxide cathode materials having different respective Mn valencies; plotting the inverse molar susceptibility values against temperatures for each of the plurality of lithium manganese spinel oxide cathode materials; determining values of at least one of two paramagnetic parameters, Weiss temperature and effective magnetic moment, by obtaining the temperature dependence of the above inverse molar susceptibility from a plot derived from the Curie-Weiss law, the Weiss temperature corresponding to a temperature value extrapolated to a zero point of the inverse molar susceptibility and the effective magnetic moment being obtainable from the gradient value of the plot; producing plural rechargeable lithium batteries in which lithium manganese spinel oxides with well-defined Mn valencies are used as cathode materials, and finding at least one of the charge or discharge capacities around 4V for each of the batteries; providing at least one correlation curve between the above-found charge and/or discharge capacities and the above-found at least one paramagnetic parameter value; and obtaining charge and/or discharge capacities for a rechargeable lithium battery containing a lithium manganese spinel oxide whose charge and/or discharge capacities are being sought from the at lest one determined paramagnetic parameter value using the at least one correlation curve. A method of determining the charge and/or discharge capacities of non-aqueous batteries with an operating voltage of about 4 volts, is also provided which includes determining a spontaneous magnetization value for each of a plurality of lithium manganese spinel oxide cathode materials having a different respective Mn valency by determining a magnetization value of each of a plurality of magnetic fields at a constant temperature to obtain and thereafter use a correlation curve.

Method for predicting discharge capacity and operating voltage of

A process for preparing LiFeO.sub.2 having a layered rock salt type structure is characterized in that at least one member selected from the group consisting of water-soluble iron salts, iron hydroxides, iron oxide hydroxides, and metallic iron is subjected to a hydrothermal treatment in an aqueous solution containing lithium hydroxide and at least one of sodium hydroxide and potassium hydroxide at 130.degree. to 300.degree. C.

Process for preparing layered rock salt type lithium ferrite by mixed

An ionic conductor comprising an oxide Na.sup.+ ionic conductor represented by the formula Na.sub.4 Zr.sub.2 Si.sub.3 O.sub.12 and a solid superacid represented by the formula SO.sub.4.sup.2- /ZrO.sub.2 incorporated therein as a dispersoid.

Ionic conductor

A method and apparatus for measuring the remaining charge of a galvanic cell effects the measurement of the remaining charge by superimposing an AC voltage or current on DC voltage or current issuing from the cell to produce a higher harmonic current or voltage, determining the value corresponding to a higher harmonic component of n'th order from the higher harmonic current or voltage, and comparing the value thus measured of the cell under test with that measured previously in the same manner of a reference galvanic cell. Since the corresponding value of the higher harmonic current or voltage of n'th order varies notably with the decrease in the remaining charge of the galvanic cell, the comparison of the found corresponding value with the reference characteristic is effected with ease and the measurement can be carried out accurately and simply.

Method and apparatus for measuring remaining charge of galvanic cell

A hydrogen-oxygen solid electrolyte fuel cell using Cu.sub.2 O as a cathode catalyst.

Hydrogen-oxygen solid electrolyte fuel cell

The humidity of a gas is adjusted by passing the gas through a plurality of compartments containing the saturated aqueous solution of a salt thereby imparting a prescribed value of humidity to the gas.

Method for adjusting the humidity of gas to a constant value

The humidity of a gas is adjusted by passing the gas through a plurality of compartments or chambers within a closed container containing the saturated aqueous solution of a salt thereby imparting a prescribed value of humidity to the gas. A plurality of partition walls are disposed at fixed intervals within the closed container defining a plurality of chambers having upper and lower interior portions and having openings formed therein alternately open into the upper and lower portions of the chambers.

Apparatus for adjusting the humidity of gas to a constant value

In the conversion of chemical energy into electric energy by the electrochemical reaction of a gaseous anodic reactant and a gaseous cathodic reactant through the medium of a heteropoly acid solid electrolyte, the life of the solid electrolyte is notably increased by passing each reactant through pools of a saturated aqueous solution of a specific salt bordering on closed empty spaces thereby allowing the reactants to acquire prescribed humidities prior to the contact thereof with the anode and cathode.

Method for conversion of chemical energy to electric energy

Disclosed is a proton permselective solid-state member which is formed of a heteropoly acid represented by the generic formula, H.sub.m [X.sub.x.sup.. Y.sub.y.sup.. O.sub.z ].sup.. nH.sub.2 O, or a salt thereof. Said permselective member can be used as an electrolyte in the fuel cell and as a permselective membrane in the hydrogen gas refining system.

Growing community of inventors

Ikeda, Japan

Osamu Nakamura