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The General Hospital Corporation

Shiseido Company, Limited

Osamu Moro

Masahiro Tajima

Ethan A Lerner

Manami Ohnuma

Kawori Wakita

There are provided a method to screen agonist or antagonist of the maxadilan receptor participating in vasodilating action, wherein a receptor of maxadilan is used, compounds which specifically bind to the receptor, and a tissue preparation having the receptor. The compounds are variants of maxadilan from the salivary glands of the sand fly.

Method for screening agonist or antagonist of the maxadilan receptor participating in vasodilating action, and compound found by the method

This specification relates to the use of peptides having a specific affinity to pituitary adenylate cyclase activating polypeptide (PACAP) receptors, particularly MAX (67 amino acids), NSP (61 amino acids) and M65 (46 amino acids). MAX and NSP act as agonists to PACAP type 1 receptors, and M65 acts as an antagonist to PACAP type 1 receptors.

Peptides having specific affinity to pituitary adenylate cyclase

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Lexington, MA, United States of America

Osamu Moro