Nippon Soda Co., Ltd.

Suntory Limited

Osamu Miyahara

Hiroyuki Adachi

Masao Yamaguchi

Akihiro Takahashi

Masaji Ishiguro

Takashi Nakatsuka

Takashi Kawana

Hiromitsu Iwata

Katsunori Tanaka

Masami Koguchi

Takahiro Sagae

Kiyoharu Nakayama

Kenichi Noguchi

3-(isoxazol-5-yl)-substituted benzoic acid derivative and method for

The present invention is directed to a compound of formula �I!: ##STR1## or a salt thereof in which R.sub.1 is a a C.sub.1-6 alkyl group, R.sup.2 is a halogen atom, a C.sub.1-6 alkylthio group, a C.sub.1-6 alkylsulfinyl group or a C.sub.1-6 alkylsulfonyl group, R.sup.3 and R.sup.4 are each independently hydrogen, a C.sub.1-6 alkyl group or a C.sub.1-6 haloalkyl group, and R is hydrogen or a C.sub.1-6 alkyl group. The present invention is further directed to a compound of formula �1! or a salt thereof, as described above and in which R.sup.1 and R.sup.3 are methyl, R.sup.2 is chlorine or methylsulfonyl, R.sup.4 is hydrogen, and R is methyl or ethyl. In addition, the present invention is directed to a herbicidal composition, characterized in that it contains as active agent one or more compounds of formula �I! or salt thereof in which R.sup.1, R.sup.2, R.sup.3, R.sup.4 are as described above.

Compound and herbicidal composition for weed control

A process for preparing an optically active tetrahydro-2-furoic acid is disclosed. The process comprises (i) reacting (.+-.)-tetrahydro-2-furoic acid with an optically active amine resolver of the following formula (I): ##STR1## wherein R.sub.1 is a lower alkyl group and R.sub.2 represents an alkyl group or ar aryl group, provided that R.sub.1 and R.sub.2 are different from each other, thus producing an optically active diastereomer salt, and (ii) decomposing the diastereomer salt. According to the process, a high purity, optically active tetrahydro-2-furoic acid can be prepared at a high yield using an amine resolver. The amine resolver can be recovered at a high yield and high purity.

Process for preparing optically active tetrahydro-2-furoic acid

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Odawara, Japan

Osamu Miyahara