Meiji Seika Kaisha, Ltd.

Meiji Seika Kabushiki Kaisha

Osamu Makabe

Kozo Nagaoka

Takashi Yoshida

Shigeharu Inouye

Shunzo Fukatsu

Yasushi Murai

Masahiro Onodera

Tuneo Okonogi

Hitoshi Ikeda

Takashi Tsuruoka

Seiji Shibahara

Taro Niida

Tsuneo Okonogi

Shigeo Seki

Yoshiyuki Koyama

Fumio Kai

Yuichi Yamamoto

Takayuki Usui

Shokichi Nakajima

Takeo Nomura

Chuhei Nojiri

Hiroyuki Hamaguchi

Susumu Nishimura

Tsutomu Tsuruoka

Yuzo Kazuno

Osamu Itoh

Shigeru Hoshiko

Kiyoyuki Ogata

Nobuko Okada

Shinichiro Kuriya

Keita Matsunaga

A novel 2-piperidinecarboxylic acid derivative represented by the formula: ##STR1## wherein X represents an oxygen atom, a sulfur atom or a nitrogen atom to which a hydrogen atom is bound; and * represents that the configuration of the carbon atom binding to the carboxyl group is (S), (R) or a mixture of (S) and (R); and a pharmaceutically acceptable salt thereof which exerts an antitumor effect over a wide range of tumor cells.

2-piperidinecarboxylic acid derivative, oncogene suppressor and agent

Megakaryocyte colony stimulating factor and process for its preparation

A DNA segment of a gene coding for a signal peptide is disclosed the segment is to be used in a host-vector system employing a bacterium belonging to the genus Streptomyces as a host by incorporation in the vector DNA. The segment comprises a DNA having a base sequence coding for the peptide having the amino acid sequence from X to Y in the annexed FIG. 1. A vector plasmid to be used for transformation of bacteria belonging to the genus Streptomyces is also disclosed. The plasmid comprises a DNA segment with a base sequence coding for an extra-cellular .alpha.-amylase derived from Streptomyces hygroscopicus SF-1084 strain or a mutant thereof the DNA segment incorporated into a vector plasmid is to be used in a host-vector system employing a bacterium belonging to the genus Streptomyces as a host and also having a DNA segment necessary for expression of the gene information of the DNA segment. The present invention may be applied to the production of a desired protein which will be secreted outside the host microorganism. .

Gene coding for signal peptides and utilization thereof

Cephalosporin compounds, intermediate compounds therefor, and processes for preparation thereof are described; the compounds have the formula (I) ##STR1## wherein R.sub.1 and R.sub.2 can each represent hydrogen, a hydroxyl group, a lower alkoxy group, or a substituted or unsubstituted phenylalkoxy group; R.sub.3 represents hydrogen or a lower alkyl group; R.sub.4 represents hydrogen or a hydroxyl group; and R.sub.5 represents ##STR2## wherein R.sub.6 is hydrogen, a lower alkyl group, an aminoalkyl group, an aminoaralkyl group, a --(CH.sub.2).sub.n --SO.sub.3 Na group, or a --(CH.sub.2).sub.n --COR.sub.9 group [wherein R.sub.9 is a hydroxyl group, an OM group (wherein M is an alkali metal), an alkoxy group, or an ##STR3## group, (wherein R.sub.10 and R.sub.11, which may be the same or different, can represent hydrogen or an alkyl group), and n is 0 or an integer of from 1 to 4]; R.sub.7 is hydrogen, a lower alkyl group, an amino group, or a substituted or unsubstituted aryl group; and R.sub.8 represents hydrogen or a lower alkyl group; or, a pharmaceutically acceptable salt thereof.

Cephalosporin compounds

Penicillin compounds and methods for the production thereof are described, said penicillin compounds being represented by the formula (I) ##STR1## wherein R.sub.1, R.sub.2, and R.sub.3 each represents hydrogen, a lower alkyl group, a halogen atom, a lower alkoxy group, a hydroxyl group, or a substituted or unsubstituted phenylalkoxy group except that R.sub.1, R.sub.2, and R.sub.3 cannot all represent hydrogen simultaneously; R.sub.4 represents hydrogen or a lower alkyl group; and R.sub.5 represents hydrogen or a hydroxyl group.

Penicillin compounds

Novel cephalosporin derivatives having formulae (V) and (III): ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.8 and A are defined as in the specification.

Cephalosporin derivatives

Growing community of inventors

Tokyo, Japan

Osamu Makabe