Sysmex Corporation

School Juridical Person Higashi-nippon-gakuen

Osamu Kumano

Takeshi Suzuki

Konobu Kimura

Masahiro Ieko

Haruki Yamaguchi

Masahiro Okuda

Kazuyo Yoshida

Naohiko Matsuo

Nobuo Arai

Yuka Tabuchi

Keisuke Nishi

Disclosed is a method for measuring a clotting time, including the steps of:

Method for measuring clotting time, measurement device for clotting time, and reagent kit

A determination method of a blood sample may include: measuring, with a first coagulation time measurement reagent and a second coagulation time measurement reagent which contain phospholipids at different concentrations, coagulation times of a blood sample of a subject, coagulation times of a normal blood sample, and coagulation times of a mixed sample including the blood sample of the subject and the normal blood sample; acquiring a first index value and a second index value based on the coagulation times; and determining whether the blood sample of the subject is a blood sample containing a direct anticoagulant based on the first index value and the second index value.

Determination method of blood sample, blood sample analyzer, and computer program

Disclosed is a method for determining a blood specimen, comprising preparing a first measurement sample by mixing a blood specimen of a subject with a first coagulation time measurement reagent and measuring first coagulation time, preparing a second measurement sample by mixing the blood specimen with a second coagulation time measurement reagent and measuring second coagulation time, and acquiring a value based on the first coagulation time and the second coagulation time, wherein the second coagulation time measurement reagent contains a metal ion and/or normal plasma, and the value is used to determine whether the blood specimen of a subject is a blood specimen containing a lupus anticoagulant or a blood specimen containing a direct anticoagulant.

Method for determining blood specimen

The present invention relates to a method for acquiring information on a cause of prolongation of coagulation time. The present invention also relates to a device, a system and a computer program for analyzing blood coagulation.

Method for acquiring information on cause of prolongation of coagulation time, and device

Disclosed is a method for measuring a clotting time, including:

Disclosed is a blood sample determination method including: preparing a mixed plasma by mixing a subject plasma and a normal plasma; emitting light to a measurement specimen obtained by mixing the mixed plasma and a clotting time measuring reagent, to obtain optical information regarding an amount of light from the measurement specimen; and determining whether the subject plasma is suspected to be a coagulation-factor-deficient plasma, on the basis of optical information obtained from one measurement specimen.

Method, apparatus, and computer program for blood sample determination, and blood sample analyzer

Disclosed is a method for measuring clotting time including: preparing a measurement sample by mixing a blood specimen suspected to contain a lupus anticoagulant, an activator, and a divalent-metal-ion-producing compound for facilitating formation of a phospholipid-containing complex; and measuring a clotting time after adding, to the measurement sample, an aqueous solution of a calcium salt as a coagulation initiator.

Method for measuring clotting time, method for determining presence or absence of lupus anticoagulant, and reagent kit for detecting lupus anticoagulant

In order to provide a reagent kit for detecting LA which can clearly separate a lupus anticoagulant (LA)-positive specimen group from an LA-negative specimen group, it is configured that the reagent kit for detecting LA contains a first clotting time-measuring reagent and a second clotting time-measuring reagent and at least one of the first clotting time-measuring reagent and the second clotting time-measuring reagent contains alkali metal salt. The presence or absence of LA can be determined using the kit.

Reagent kit for detecting lupus anticoagulant and method of determining presence or absence of lupus anticoagulant

The present invention provides a reagent kit for detecting lupus anticoagulant which includes a first clotting time-measuring reagent containing manganese salt and a second clotting time-measuring reagent which contains manganese salt at a concentration lower than that of the first clotting time-measuring reagent or does not contain manganese salt and a method of determining the presence or absence of lupus anticoagulant using the kit.

Growing community of inventors

Kobe, Japan

Osamu Kumano