Chugai Seiyaku Kabushiki Kaisha

Osamu Kondoh

Kazuo Hattori

Toshiyuki Tsukaguchi

Takehiro Okada

Satoshi Niizuma

Satoshi Tanida

Miyako Masubuchi

Masaki Shibata

Kohei Koyama

The present invention provides a compound of the formula (I) or a pharmaceutically acceptable salt thereof: 

1-(2H)-isoquinolone derivative

The present invention provides a compound having high antitumor activity, which is useful for therapeutic and preventive agents effective for proliferative diseases such as cancer; a production method thereof; an intermediate compound useful for such production; and a pharmaceutical composition comprising such a compound. The present invention provides a compound represented by the formula (1): wherein X represents an aryl group or heteroaryl group which may be substituted, Cy represents a 4- to 7-membered monocyclic heterocyclic ring or a 8- to 10-membered condensed heterocyclic ring which may be substituted, and Z represents O, S, or NRa; or a prodrug thereof; or a pharmaceutically acceptable salt thereof; and a pharmaceutical and a pharmaceutical composition which comprise the compound.

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Kamakura, Japan

Osamu Kondoh