Maruko Seiyaku Co., Ltd.

Osamu Komatsu

Sachio Ohno

Kiyoshi Mizukoshi

Mitsuaki Nagasaka

Hajimu Yamamoto

Yoshiki Nakamura

Yasuo Kunou

Takashi Morishima

Kenzi Ichihara

Novel pyridine compounds and the pharmaceutically acceptable salts thereof having a specific inhibitory activity on thromboxane A.sub.2 biosynthesis in mammals useful for prevention and treatment of various disorders caused by thromboxane A.sub.2, for example, thrombosis, cardiac infarction, diabetic vascular complications, asthma, etc. are disclosed.

Certain pyridyloxy-or-thio-phenyl propenoic acid derivatives

1,4-Dihydropyridine compounds having excellent coronary and vertebral vasodilation, blood pressure depression and anti-hypertensive activities are disclosed. These compounds are low toxic and stable to light, and are very useful for pharmaceutical agents.

1,4-Dihydropyridine compounds

Novel thiopyranopyrimidine compounds and the pharmaceutically acceptable acid addition salts thereof having excellent hypoglycemic activity, platelet aggregation inhibitory activity, antihistamine activity and anti-allergy activity useful for prevention and treatment of various disorders caused by diabetes, allergy and the like are disclosed.

Thiopyranopyrimidine compounds and acid addition salts thereof

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Aichi, Japan

Osamu Komatsu