Mercian Corporation

Osamu Johdo

Takeo Yoshioka

Kiyotomo Nakamura

Takuma Nakao

Konomi Iguchi

Disclosed are a crystalline form of anthracycline antibiotic having specific characteristic 2&thgr; values as measured by the X-ray diffraction method, and a process for producing the crystalline form. This process comprises the step of crystallization involving the combined use of a specific poor solvent for the antibiotic and a good solvent thereof. This crystalline form has excellent chemical and physical properties.

Crystalline anthracycline antibiotic and process for producing the same

Disclosed are a crystallizing method of doxorubicin hydrochloride from a doxorubicin hydrochloride-containing solution, particularly a method for carrying out the crystallization under a condition of 40&deg; C. or higher, and a doxorubicin hydrochloride crystalline aggregate having particularly an excellent solubility in water.

Crystallization of doxorubicin hydrochloride

The present invention relates to a method in which daunomycin is eluted from a hydrophobic porous synthetic resin carrier onto which daunomycin is adsorbed from crude daunomycin with a buffered aqueous solution containing a water-miscible organic solvent to recover purified daunomycin. Daunomycin (daunorubicin) is purified efficiently.

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Fujisawa, Japan

Osamu Johdo