Daiichi Sankyo Company, Limited

Tokuyama Corporation

Tokuyama Soda Kabushiki Kaisha

Osamu Iwamoto

Yasuyuki Ogawa

Keiji Saito

Katsuyoshi Nakajima

Nobuya Kurikawa

Kazumasa Aoki

Toru Taniguchi

Kaori Ito

Eriko Kioi

Shinji Tanaka

Natsumi Nishihama

Wataru Saitoh

Momoko Ogitani

Satoshi Shibuya

Tsuyoshi Mikkaichi

Yasuhiro Hosoi

Masato Sekino

Masaaki Ushioda

Hidenori Takahashi

Koshi Kusumoto

Masataka Himeno

Mikio Kato

Kyoichi Fujinami

Seiko Nagata

Yoshikazu Uto

Hiroko Kono

Toru Ono

Nobuyuki Ohkawa

Hiroyuki Tsuruoka

Tsuyoshi Soneda

Hiroyuki Nakagawa

Junya Kawai

Shinichiro Kunimoto

Takaaki Imakura

Yasuhiro Ogawa

Yuma Umezaki

Tomohiro Honda

An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof. The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof. wherein the symbols in the formula are defined below: A: e.g., Benzene, E: e.g., —CH—, G: e.g., a 5-membered aromatic heterocyclic ring, X: e.g., cyclohexane, J: e.g., a 5-membered aromatic heterocyclic ring, Y: e.g., a phenyl group, R, R, R: e.g., a halogen atom, R: e.g., a C1-C6 alkyl group, R: e.g., a hydrogen atom, R, R, R, R: e.g., a hydrogen atom, R: e.g., a hydrogen atom, R: e.g., a hydrogen atom, n, n, n: e.g., 1.

Compound having cyclic structure

An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof. The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof. wherein the symbols in the formula are defined below: R: e.g., a C1-C6 alkyl group; R: a C1-C6 alkyl group; A: e.g., an oxygen atom; and R: e.g., a C1-C6 alkyl group.

Griseofulvin compound

An object of the present invention is to provide a compound that has a specific chemical structure having an activation effect on SIRT6 and is useful as an active component for preventing and treating inflammatory diseases, and the present invention relates to a compound represented by Formula (1) or a pharmaceutically acceptable salt thereof,

Urea compound having substituent

An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof. The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof. wherein the symbols in the formula are defined below:R: e.g., a C1-C6 alkyl group; R: a C1-C6 alkyl group;A: e.g., an oxygen atom; and R: e.g., a C1-C6 alkyl group.

An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof. The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof. wherein the symbols in the formula are defined below:A: e.g., Benzene, E: e.g., &#x2014;CH&#x2014;, G: e.g., a 5-membered aromatic heterocyclic ring, X: e.g., cyclohexane, J: e.g., a 5-membered aromatic heterocyclic ring, Y: e.g., a phenyl group, R, R, R: e.g., a halogen atom, R: e.g., a C1-C6 alkyl group, R: e.g., a hydrogen atom, R, R, R, R: e.g., a hydrogen atom, R: e.g., a hydrogen atom, R: e.g., a hydrogen atom, n, n, n: e.g., 1.

It is an object of the present invention to provide a medicament for preventing or treating hyperphosphatemia. Solution: A compound represented by a general formula (I) or a pharmacologically acceptable salt thereof. (In the formula, R: a methyl group or the like, R: a hydrogen atom or the like, R: a hydrogen atom or the like, A: a cyclohexyl ring or the like, X: CH or the like, Y: CH or the like, Z: CH or the like, and n: 2 or the like).

Dicarboxylic acid compound

It is an object of the present invention to provide a medicament for preventing or treating hyperphosphatemia. Solution: A compound represented by a general formula (I) or a pharmacologically acceptable salt thereof. [In the formula, R: a methyl group or the like, R: a hydrogen atom or the like, R: a hydrogen atom or the like, A: a cyclohexyl ring or the like, X: CH or the like, Y: CH or the like, Z: CH or the like, and n: 2 or the like].

A method of preparing a ceramic artificial crown by applying at least one kind of dental porcelain onto the surface of a ceramic core molded by heating and softening a ceramic material and putting it into a mold with the application of pressure followed by firing wherein said mold is the one formed by burning a wax pattern after having removed a crucible former from an assembly which makes it possible to efficiently prepare a fully ceramic artificial crown of a high quality in a short period of time.

Method of preparing a ceramic artificial crown and a preparation kit used therefor

Method of producing ceramic crowns

A method which comprises using silicone rubber as a material for dental tissue conditioner.

Dental tissue conditioner and kit therefor

Provided is a porcelain which is suitable as a dental porcelain capable of being fired on a ceramics core and has a low firing temperature and a low thermal expansion coefficient and which is excellent in a chemical durability. The above dental porcelain comprises glass containing silicon oxide, aluminum oxide, boron oxide, zinc oxide, sodium oxide and lithium oxide as principal components. The contents of these respective components in the above glass are 57 to 65% by weight of SiO,, 8 to 18% by weight of Al,O,, 15 to 25% by weight of B,O,, 0.1 to 2% by weight of ZnO, 3 to 7% by weight of Na,O and 2 to 8% by weight of Li,O respectively in terms of a percent by weight based on the total of the respective components when the respective components are reduced to SiO,, Al,O,, B,O,, ZnO, Na,O and Li,O respectively. The particularly preferred dental porcelain comprises glass having a thermal expansion coefficient of 6.0&times;10,(1/&deg;C.) or less as a principal structural component.

Dental porcelain

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Yokohama, Japan

Osamu Iwamoto