Meiji Seika Kaisha, Ltd.

Vlsi Technology Research Association

Osamu Itoh

Shigeharu Inouye

Takashi Tsuruoka

Taro Niida

Mitsugu Hachisu

Yasuharu Sekizawa

Uichi Shibata

Takemi Koeda

Hiroyasu Asaoka

Seiji Shibahara

Tsuneo Okonogi

Yuichi Yamamoto

Takayuki Usui

Osamu Makabe

Susumu Nishimura

Tsutomu Tsuruoka

Kozo Nagaoka

Nobuo Wakatsuki

Nobuko Okada

A novel 2-piperidinecarboxylic acid derivative represented by the formula: ##STR1## wherein X represents an oxygen atom, a sulfur atom or a nitrogen atom to which a hydrogen atom is bound; and * represents that the configuration of the carbon atom binding to the carboxyl group is (S), (R) or a mixture of (S) and (R); and a pharmaceutically acceptable salt thereof which exerts an antitumor effect over a wide range of tumor cells.

2-piperidinecarboxylic acid derivative, oncogene suppressor and agent

For test, a sequential circuit operable in a normal and a shift mode is logically divided into a plurality of partitions, each comprising a first and a second sequence of registers. A testing device specifies the first sequence in each partition, one partition after another, and supplies the registers of the specified first sequence, in the shift mode, with a test pattern prescribed for the specified partition. A pattern resulting from the test pattern is supplied in the normal mode to the registers of the second sequence in the specified partition and shifted out thereof subsequently in the shift mode to be compared with a correct or reference pattern predetermined for the test pattern for detection of a fault. For location of the fault in the specified partition, the test and the shifted-out patterns are combined into a combined pattern, which is supplied to the registers of the first and the second sequences in the normal mode following the shift mode in which the fault is detected.

Method and device for testing a sequential circuit divided into a

5-Alkoxy-picolinic esters represented by the formula (I): ##STR1## wherein R represents an alkyl group having 1 to 6 carbon atoms and R.sub.1 represents an unsubstituted phenyl group; a phenyl group substituted with one or more of an alkyl group having 1 to 4 carbon atoms or an acetyl group; a phthalidyl group; an alkoxyalkyl group wherein the alkyl moiety and the alkoxy moiety each has 1 to 4 carbon atoms; an alkoxyalkoxyalkyl group wherein the alkyl moiety and the alkoxy moiety each has 1 to 4 carbon atoms; an indanyl group; or an acyloxyalkyl group having the formula ##STR2## wherein R.sub.2 represents a hydrogen atom or a methyl group and R.sub.3 represents an alkyl group having 1 to 5 carbon atoms (such as a methyl, n-propyl, isobutyl, t-butyl, etc., group), an alkoxy group having 1 to 4 carbon atoms, a phenyl group, a phenyl group substituted with one or more of an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms or a halogen atom (such as chlorine, bromine, iodine, etc., atom) or an aralkyl group wherein the alkyl moiety has 1 to 3 carbon atoms, which are useful as anti-hypertensive agents, a process for preparing 5-alkoxy-picolinic esters, and anti-hypertensive compositions containing the 5-alkoxy-picolinic esters.

5-Alkoxy-picolinic esters and anti-hypertensive composition containing

5-Alkoxy-picolinic acids and the salts and the esters thereof represented by the formula (I): ##STR1## wherein R represents an alkyl group having 1 to 6 carbon atoms and M represents a hydrogen atom; a calcium atom; a sodium atom; a potassium atom; an aluminum atom; an unsubstituted phenyl group; a phenyl group substituted with one or more of an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms or a halogen atom (such as a chlorine, bromine, iodine, etc., atom); a phthalidyl group; an alkoxyalkyl group wherein the alkyl moiety and the alkoxy moiety each has 1 to 4 carbon atoms; or an acyloxyalkyl group having the formula ##STR2## wherein R.sub.2 represents a hydrogen atom or a methyl group and R.sub.3 represents an alkyl group having 1 to 5 carbon atoms (such as a methyl, n-propyl, isobutyl, t-butyl, etc., group), an alkoxy group having 1 to 4 carbon atoms, a phenyl group, a phenyl group substituted with one or more of an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms or a halogen atom (such as a chlorine, bromine, iodine, etc., atom) or an aralkyl group wherein the alkyl moiety has 1 to 3 carbon atoms, which are useful as anti-hypertensive agents, a process for preparing 5-alkoxy-picolinic acids and the salts and the esters thereof, and anti-hypertensive compositions containing the 5-alkoxy-picolinic acids and the salts and the esters thereof.

5-Alkoxy-picolinic acid calcium salts and anti-hypertensive composition

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Tokyo, Japan

Osamu Itoh