Eisai Company, Limited

Eisai R&d Management Co., Ltd.

Japan International Research Center for Agricultural Sciences

Osamu Ito

Richard S Clark

Tetsuya Kawahara

Mitsuaki Miyamoto

Fumihiro Ozaki

Kazuo Okano

Nobuaki Sato

Akiharu Kajiwara

Ieharu Hishinuma

Hiroshi Tanaka

Masanobu Shinoda

Fumiyoshi Matsuura

Itaru Tsukada

Atsushi Kamada

Makoto Kotake

Taro Terauchi

Toshiyuki Matsuoka

Yoshimitsu Naoe

Shuichi Suzuki

Shinro Tachibana

Motoji Kogushi

Akifumi Kimura

Hiroko Kobayashi

Ken-ichi Chiba

Naoto Ono

Syuhei Miyazawa

Yoshiaki Oohashi

Manabu Ishitani

Tsutomu Kawata

Hiroshi Ono

Takashi Musha

Mayumi Kameyama

Marco Rondon

Tsutomu Kawada

Takashi Musya

Guntur V Subbarao

Kazuhiko Nakahara

Takayuki Ishikawa

Carlos Lascano

Idupulapati Madhusudana Rao

Mitsuru Yoshida

Ken-Ichi Chiba

Keni-Ichi Chiba

Takashii Musha

A nitrification inhibitor and a soil improver and a fertilizer containing the same are offered which can be utilized in a wide area from a tropical to a temperate zone, and can be easily obtained from natural origin materials. It is a nitrification inhibitor to inhibit soil nitrification, containing as a main component either one of linoleic acid, &#x3b1;-linolenic acid, &#x3b3;-linolenic acid, and methyl linoleate, or their mixture of two or more. By incorporating this nitrification inhibitor into a soil improver or a fertilizer, nitrification of soil can be effectively inhibited.

Nitrification inhibitor and soil improver and fertilizer containing the same

A 2-iminoimidazole derivative represented by the formula: {wherein R, Rand Rrepresent hydrogen, optionally substituted Calkyl, etc.; Rrepresents hydrogen, Calkyl, Calkyloxycarbonyl, etc.; Yrepresents a single bond, &#x2014;CH&#x2014;, etc.; Yrepresents a single bond, &#x2014;CO&#x2014;, etc.; and Ar represents hydrogen, a group represented by the formula: [wherein R&#x2013;Rrepresent hydrogen, Calkyl, hydroxyl, Calkoxy, etc., and Rand Ror Rand Rmay bond together to form a 5- to 8-membered heterocycle], etc.}or salt thereof.

2-iminoimidazole derivatives (2)

A 2-iminopyrrolidine derivative represented by the formula: {wherein ring B represents a benzene ring, pyridine ring, etc.; R&#x2013;Rrepresent hydrogen, halogen, Calkyl, etc.; Rrepresents hydrogen, Calkyl, Calkoxy-Calkyl, etc.; Rrepresents hydrogen, Calkyl, Calkyloxycarbonyl, etc.; Yrepresents a single bond, &#x2014;CH&#x2014;, etc.; Yrepresents a single bond, &#x2014;CO&#x2014;, etc.; and Ar represents hydrogen, a group represented by the formula: [wherein R&#x2014;Rrepresent hydrogen, Calkyl, hydroxyl, Calkoxy, etc.; and Rand Ror Rand Rmay bond together to form a 5- to 8-membered heterocyclic ring], etc.},or a salt thereof.

2-iminopyrrolidine derivatives

A peptide is novel and useful for the bronchodilative activity and the hypotensive activity, having the following structure:

Physiologically active peptide

A peptide is novel and useful for the bronchodilative activity and the hypotensive activity, having the following structure: ##STR1## (wherein X is Met or Leu; and Y is OH, Lys-OH, Arg-OH, Lys-Arg-OH, or Lys-NH.sub.2 when X is Met, or Y is Lys-NH.sub.2, Lys-OH, or Lys-Arg-OH when X is Leu).

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Tsukuba, Japan

Osamu Ito