Nihon Medi-physics Company, Limited

Osamu Ito

Akio Hayashi

Masahito Toyama

Fumie Kurosaki

Toshiyuki Shinmura

Arinori Harano

Yoshitoshi Itaya

Masaru Kanagawa

Masamichi Hara

Yasuko Watanabe

Aki Morishita

Nobuhiko Kanazashi

It is intended to provide a novel amino acid organic compound which can be used as a labeling precursor compound for radioactive halogen-labeled amino acid compounds including [F]FACBC, and which prevents methanol from remaining in the radioactive halogen-labeled amino acid compounds produced therefrom. The novel amino acid organic compound is a compound represented by the following formula: wherein n is an integer of 0 or of 1 to 4; Ris an ethyl, 1-propyl or isopropyl substituent; X is a halogen substituent or a group represented by &#x2014;OR; Ris a straight-chain or branched-chain haloalkylsulfonic acid substituent with one to 10 carbon atoms, trialkylstannyl substituent with 3 to 12 carbon atoms, fluorosulfonic acid substituent or aromatic sulfonic acid substituent; and Ris a protective group.

Precursor compound of radioactive halogen-labeled organic compound

It is intended to provide a novel amino acid organic compound which can be used as a labeling precursor compound for radioactive halogen-labeled amino acid compounds including [F]FACBC, and which prevents methanol from remaining in the radioactive halogen-labeled amino acid compounds produced therefrom. The novel amino acid organic compound is a compound represented by the following formula:  wherein n is an integer of 0 or of 1 to 4; Ris an ethyl, 1-propyl or isopropyl substituent; X is a halogen substituent or a group represented by &#x2014;OR; Ris a straight-chain or branched-chain haloalkylsulfonic acid substituent with one to 10 carbon atoms, trialkylstannyl substituent with 3 to 12 carbon atoms, fluorosulfonic acid substituent or aromatic sulfonic acid substituent; and Ris a protective group.

Unnatural amino acid radiolabeling precursor

It is intended to provide a labeling precursor compound used for selectively producing radioactive halogen-substituted syn-1-amino-3-cyclobutane-carboxylic acids, and to provide a process for producing a radioactive halogen-substituted syn-1-amino-3-cyclobutane-carboxylic acid using the labeling precursor compound. A labeling precursor is used in which a phthalimide group is used as a protective group for protecting the amino group. The syn-form of the radioactive halogen-substituted 1-amino-3-cyclobutane-carboxylic acid can be selectively produced by labeling the labeling precursor with a radioactive halogen followed by deprotecting.

Organic compound and method for producing radioactive halogen-labeled organic compound using the same

Bisphosphonic acid derivative and compound thereof labeled with radioactive nuclide

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Chiba, Japan

Osamu Ito