Nippon Kayaku Kabushiki Kaisha

Osamu Ishizuka

Takashi Terada

Tochiro Tatee

Takashi Takahira

Makoto Hosono

Yasuhiko Furuta

Giichi Izumi

Michiko Sakai

Junpei Itoh

Akira Fujita

The present invention relates to novel pharmaceutical use of forskolin derivatives represented by the general formula: ##STR1## wherein R.sup.1, R.sup.2 and Ac are as defined later ##STR2## (wherein R.sup.3 and R.sup.4 are each hydrogen or lower alkyl group, or R.sup.3 and R.sup.4 may be combined to represent lower alkylene group which may have oxygen or nitrogen atom in the linking chain, and n is an integer of 1 to 5); R.sup.2 represents hydrocarbon group having 2 to 3 carbon atoms; and Ac represents acetyl group. The above-mentioned forskolin derivative or a physiologically acceptable salt thereof can be used as a platelet aggregation inhibiting or controlling agent, spasmolytic agent, therapeutic agent for skin ulcer, peripheral circulation improving agent for limbs and differentiation inducing and promoting agent.

Pharmaceutical use of forskolin derivatives

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Tokyo, Japan

Osamu Ishizuka