Hisamitsu Pharmaceutical Company, Inc.

Osamu Iijima

Takashi Shimada

Takeshi Goto

Katsuhiko Akiyama

Yosuke Suzuki

Hidekazu Kuma

Norio Matsukura

An antisense oligonucleotide characterized in that it hybridizes specifically with chromosomal DNA and/or RNA encoding CXCR4 protein to thereby inhibit the expression of the CXCR4 protein, and a HIV infection inhibitor comprising the antisense oligonucleotide, are disclosed.

HIV infection inhibitors

A therapy for a disease, e.g., gastric cancer, comprising endoscopic local administration of a vector having a gene for treatment or cells producing the vector to a lesion to transduce the gene into target cells. The direct in vivo transduction of a gene for treatment into the affected site is expected to produce therapeutic effects specific on the lesion. Since the gene is introduced also into lymph nodes which may have developed a metastatic lesion, both the primary lesion and the metastatic lesion in the surrounding lymph nodes can be treated simultaneously.

Endoscopic administration of an HSV-tk gene to treat digestive organ

Gene transfer preparation

Growing community of inventors

Tsukuba, Japan

Osamu Iijima