Fujisawa Pharmaceutical Company, Ltd.

Astellas Pharma Gmbh

Nissho Corporation

Nissan Motor Company Limited

Osamu Aoki

Seizo Sunago

Hitoshi Futagawa

Norio Ohnishi

Kiyonori Okada

Shuji Hasegawa

Atsuo Ohike

Hiroshi Ishikuro

Kohji Ikeda

Kazuto Okimoto

Keita Iritsuki

Takeshi Shiomi

Kazuyuki Satou

This invention relates to a vitreous form of 8-[3-[N-[(E)-3-(6-acetamidopyridin-3-yl)acryloylglycyl]-N-methylamino]-2,6-dichlorobenzyloxy]-2-methylquinoline (FR173657). This vitreous form has good solid stability and, therefor, is useful for producing and supplying FR173657 products whose quality is stable enough to be suitable for medicines.

Vitreous form of known bradykinin antagonist

The invention relates to a vitreous form of the compound, FR 173657, having the structure of formula (I). This vitreous form has good solid stability and is therefore useful for producing and supplying FR 173657 products whose quality is stable enough to be suitable for medicine.

A transfusion device comprising a flexible vessel containing a solvent fluid, a plugged drug container containing a drug, and a communicating portion for communicating the vessel and the container with each other, the communicating portion comprising a communicating passage disposed at a top portion of the flexible vessel and having the drug container partially or wholly fitted therein, a plugged mouth portion of the container facing downward, a membrane disposed in the communicating passage for closing the passage, and a particular puncturing needle unit mounted in the communicating passage for enabling the vessel and container to communicate with each other. When the puncturing needle unit is pressed externally through the flexible vessel, the needle breaks the membrane and the plug member of the drug container to enable the vessel and container to communicate with each other.

Transfusion device

A transfusion device comprising a flexible vessel containing a solvent fluid, a drug container containing a drug, and a communicating portion for communicating the vessel and the container with each other, the commuicating portion comprising first and second passages adapted to communicate with the vessel and container and held in engagement with each other, a membrane and a plug member which are provided for closing the two communicating passages, and a particular cap held in thread engagement with the second communicating passage for enabling the two passages to communicate with each other. When the vessel and the container are rotated relative to each other, the cap slides to disengage the plug member of the second communicating passage and break the membrane of the first communicating passage, thereby allowing the vessel and the container to communicate with each other.

Medical fluid container

Disclosed is a fluid container having a flexible bag containing a diluent and having a closing film at its upper end, a capsule connected to the flexible bag, a drug container held in the capsule and a communicating member for communicating the flexible bag with the drug container. The communicating member has a double-edged hollow needle having a hub in the midway thereof, and a controlling mechanism for controlling the order of communication in such a manner that the plug of the drug container is stuck with one edge of the needle and thereafter the closing film of the flexible bag is stuck with the other end of the needle. The mixing procedure is sure and simple, and can be carried out in a short period of time.

Fluid container

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Osaka, Japan

Osamu Aoki