King Abdulaziz University

Virginia Commonwealth University

Osama A A Ahmed

Khalid Mohamed El-Say

Usama Ahmed Fahmy

Tarek Abdelnapy Ahmed

Ashraf B Abdel-Naim

Nabil Abdulhafiz Alhakamy

Shaimaa M Badr-Eldin

Bader M Aljaeid

Abdelsattar Mansour Omar

Martin K Safo

Raed Felimban

Waleed Rizg

Hani Zakariah Asfour

Omar D Al-hejaili

Basma Ghazi Eid

Sabrin R M Ibrahim

Mohammed Z Nasrullah

Amgad Khedr

Gamal A Mohamed

Mohamed W Alrabei

Amir I Mohamed

Noura A Hassan

Ahmad S Azhar

Mahmoud M El-Mas

Abdullah A Alamoudi

Hany El-Bassossy

A nano-pharmaceutical formulation, comprising zein nanoparticles, icariin (ICA) or a pharmaceutically acceptable salt thereof encapsulated within the zein nanoparticles, at least one solubilizer, wherein the at least one solubilizer comprises D-a-Tocopherol polyethylene glycol 1000 succinate (TPGS), and one or more pharmaceutical penetration enhancers is provided. Methods of enhancing libido by administering a composition as described herein is also provided.

Icariin nano-pharmaceutical formulation

Thioctamer, a nanoconjugate of glatiramer acetate (GA) and thioctic acid (TA), e.g. in the form of nanospheres, is provided as are compositions comprising thioctamer and methods of using the same for wound healing. Application of thioctamer to a wound accelerates wound healing, compared to control wounds that are not treated with the copolymer.

Thioctamer expedites wound healing

A transdermal film formulation containing transfersomes incorporated onto the transdermal film is provided. The transfersomes include avanafil, a phospholipid, and an edge activator, wherein the phospholipid to avanafil ratio is from 3.5:1 to 4.5:1 and wherein the edge activator has a hydrophilic-lipophilic (HLB) value of 2-4. Methods of making the transdermal film formulation and methods of delivering avanafil using the transdermal film formulation are also provided.

Transfersome-containing transdermal film formulations and methods of use

Micelle formulations comprising a tocopherol or derivative thereof, alpha lipoic acid, and a biologically active agent such as vinpocetine are provided. Films for transdermal delivery containing the micelle formulation and methods of treating cognitive and cerebrovascular disorders are also provided.

Micellles containing alpha lipoic acid as a transdermal drug delivery system

Nanosized avanafil (AVA) invasomes with enhanced transdermal delivery are provided. AVA invasomes were prepared with a vesicular size of 109.92 nm and an entrapment efficiency of 96.98%. The AVA invasomal film showed enhanced ex vivo permeation bioavailability compared to a raw AVA film.

Development of an optimized avanafil-loaded invasomal transdermal film

Methods of enhancing cognition and/or memory and methods of treating cognitive and cerebrovascular disorders by intranasally administering an in situ gelling composition comprising micelles formed with tocopherol or a derivative thereof are provided. The micelles encapsulate a biological active agent such as vinpocetine. The methods provide for enhanced brain targeting of the biological active agent.

In situ gelling composition containing tocopherol-loaded micelles as an intranasal drug delivery system

A nano-pharmaceutical formulation, comprising pumpkin seed oil; D-&#x3b1;-tocopheryl polyethylene glycol succinate (TPGS); and polyethylene glycol (PEG) 200 is provided. Additional cardioprotective therapies such as quercetin may be included in the formulation. Methods of treating cardiac dysfunction by administering the formulation are also provided.

Cardioprotective nano-pharmaceutical formulation

Dapoxetine nanoparticles comprising zein and alpha lipoic acid (ALA) are provided. When present in zein-ALA loaded nanoparticles, dapoxetine exhibits increased bioavailability (compared to conventional formulations) when administered to subjects for the prevention or treatment of premature ejaculation (PE). Thus, lower doses are administered, and side effects are attenuated or eliminated.

Polymeric nanoparticulate formulation to enhance the oral bioavailability of dapoxetine

Growing community of inventors

Jeddah, Saudi Arabia

Osama A A Ahmed