The University of Texas System

University of Toronto

Orson W Moe

Sachdev Singh Sidhu

Makoto Kuro-o

Sarah L Barker

Kytai Truong Nguyen

Charles Y C Pak

Khashayar Sakhaee

Connie C Hsia

Johanne Pastor

Yi Hong

Makoto Kuro-O

Charles Yc Pak

Charles YC Pak

Sachdev S Sidhu

Nanoparticles coated with extracellular matrix (ECM) are provided, in some aspects, for the delivery of a therapeutic protein, nucleic acid, or drug. In some embodiments, the nanoparticles are delivered to a subject via inhalation or aerosol delivery. Also provided, in some aspects, are methods for treating acute lung injury comprising administering &#x3b1;-Klotho (&#x3b1;Klotho) protein or DNA to a subject.

Nanoparticles containing extracellular matrix for drug delivery

An antibody and/or binding fragment thereof, wherein the antibody and/or binding fragment thereof comprises a light chain variable region and a heavy chain variable region, the light chain variable region comprising complementarity determining region (CDR) CDR-L3 and the heavy chain variable region comprising CDR-H1, CDR-H2 and CDR-H3, with the amino acid sequences of said CDRs comprising one or more of the sequences set forth below: CDR-L3; selected from any one of SEQ ID NOs: 123, 126-130, 142, 148 or 149; CDR-H1: SEQ ID NOs: 121 or 124; CDR-H2; SEQ ID NOs: 122 or 125; and/or CDR-H3: selected from any one of SEQ ID NOs: 196-226.

Antibodies that specifically bind alpha klotho

Provided herein are nanoparticles comprising antisense-encoded erythropoietin receptor (RopE) alone or in combination with erythropoietin receptor (EpoR). Also provided herein are methods of treating or preventing lungs disorders comprising administering RopE alone or in combination with EpoR.

Compositions comprising antisense-encoded erythropoietin receptor and use thereof

An antibody and/or binding fragment thereof, wherein the antibody and/or binding fragment thereof specifically binds to an epitope of a &#x3b1;Klotho polypeptide, optionally a folded &#x3b1;Klotho or optionally with a dissociation constant (K) of about 2 nM or less, as measured by competitive ELISA assay, methods of making and using to diagnose kidney diseases.

Nucleic acids encoding antibodies with high affinity for Alpha-Klotho

Antibodies which specifically bind &#x3b1;Klotho polypeptide

An antibody and/or binding fragment thereof, wherein the antibody and/or binding fragment thereof specifically binds to an epitope of a &#x3b1;Klotho polypeptide, optionally a folded &#x3b1;Kiotho or optionally with a dissociation constant (K) of about 2 nM or less, as measured by competitive ELISA assay, methods 0 of making and using to diagnose kidney diseases.

Antibodies with high affinity for alpha-Klotho

Disclosed is an effervescent preparation of calcium and magnesium with additional citric acid in a defined ratio. Also disclosed is the use of these compositions to raise cardioprotective citrate and magnesium in serum to help prevent heart attacks from calcium supplements, and to provide bioavailable calcium and magnesium to prevent osteoporosis-related fractures and low blood magnesium from the use of proton pump inhibitors.

Growing community of inventors

Dallas, TX, United States of America

Orson W Moe