Dibra S.p.a.

Bracco Imaging S.p.a.

Ornella Gazzotti

Marino Brocchetta

Fulvio Uggeri

Pier Lucio Anelli

Christoph De Haen

Luciano Lattuada

Massimo Visigalli

Enrico Cappelletti

Pierfrancesco Morosini

Giovanna Lux

Giuseppe Manfredi

Michele Serleti

Daniela Palano

Lucio Pier Anelli

The present invention relates to a process for the preparation of 5-[(2-hydroxyacyl)amino]-2,4,6-triiodo-1,3-benzendicarboxamidic derivatives comprising the Smiles rearrangement of a suitable precursor, by contact of an aqueous solution of this latter with an anion exchanger solid phase.

Process for the preparation of contrast agents

Blood pool imaging contrast agents containing paramagnetic bi- and tri-valent metal ion chelates of bile acid conjugates with molecules having chelating activity are used in magnetic resonance imaging of the vascular system and particularly the coronaries.

Use of bile acid conjugates, derivatives thereof with metal complexes as blood pool agents for nuclear magnetic resonance diagnostics

Process for the manufacturing of iodinated contrast agents

A process for the preparation of compounds of general formula (I) ##STR1## characterized in that the corresponding derivatives of general formula (II) ##STR2## are reacted with the compounds of general formula (III) ##STR3## wherein Z is halogen atom or a reactive residue of a sulfonic acid or a --N.sup.+ (R.sub.9).sub.3 cation wherein R.sub.9 is a (C.sub.1 -C.sub.6) alkyl group and

Tetraiodopyrrole derivatives as contrast medium and as antiseptic

Growing community of inventors

Pianengo, Italy

Ornella Gazzotti