Sigma-tau Industrie Farmaceutiche Riunite S.p.a.

Inverni Della Beffa Industria Chimico Farmeceutica Derivati Naturali

Orlando Ghirardi

Maria Ornella Tinti

Fabio Giannessi

Domenico Misiti

Roberto Cozzolino

Bruno Gabetta

Paolo Carminati

Carlo Scolastico

Piero Foresta

Patrizia Minetti

Aldo Cristoni

Maria Assunta Di Cesare

Carlo Sclolastico

Derivatives of pyrrolo[2,1-b]benzothiazepines with formula (I) where A is CH&#x2014;CHC&#x2550;CH; R is hydrogen, halogen, C-Calkoxy, C-Calkylthio, C-Calkyl, C-Ccycloalkyl; Ris 1-peperazinyl, 1-homopiperazinyl and 1-piperidinyl; Ris hydrogen, C-Calkoxy, C-Calkylthio, C-Calkyl, CHO, CH&#x2550;NOH,CHOH. The formula (I) compounds are endowed with characteristic atypical anti-psychotic activity, and are therefore useful as medicaments, in particular for the treatment and prevention of schizophrenia, paranoid states, manic-depressive states, disorders of the affective sphere, social regression, personality regression, and hallucinations. Said compounds also present advantageous pharmacokinetic properties.

Dealkylated derivatives of pyrrolo[2,1-b]benzothiazepines with atypical antipsychotic activity

Orally or parenterally administrable pharmaceutical compositions in unit dosage form comprise from about 100 to about 500 mg of one of the compounds of formula (I). ##STR1## wherein R is selected from: 2-(N,N-diisopropyl)aminoethyl,

Pyroglutamic acid derivatives as enhancers of learning processes and

1,2,3,4-tetrahydronaphthlamines of formula (1) ##STR1## wherein R is H or OCH.sub.3 ; ##STR2## is either at 1 or 2 position R.sub.1 is H;

Derivatives of 1,2,3,4-tetrahydronaphtylamine endowed with nootropic

Pharmaceutical compositions for enhancing the process of learning and memory are disclosed, that contain as active principle a 3-amino-.epsilon.-caprolactam of formula (1) ##STR1## Wherein R is selected from the group consisting of hydrogen, formyl and acetyl. Orally or parenterally administrable pharmaceutical compositions in unit dosage form comprise from about 100 to about 500 mg of a compound of formula (1).

Pharmaceutical compositions comprising 3-amino-.epsilon.-caprolactames

1-acyl-2-pyrrolidinones of general formula (I) ##STR1## wherein R is selected from the group consisting of: phenyl substituted with halogen-substituted lower (C.sub.1 -C.sub.4) alkyl;

1-acyl-2-pyrrolidinones as enhancers of learning and memory

(Pyrrolidin-2-one-1-yl)acetamides of general formula (I) ##STR1## wherein R is hydrogen or hydroxyl, R.sub.1 is hydrogen, R.sub.2 is selected from the group consisting of:

(Pyrrolidin-2-one-1-yl) acetamides and enhancers of learning and memory

Triterpene saponins of formula ##STR1## wherein R.sub.1 is H or OH and R.sub.2 is a tetrasaccharide, or alternatly pentasaccharide, chain have antiinflammatory, mucolytic and antiedemic activities. Said saponins are isolated from roots and bark of Crossopteryx febrifuga, for instance by precipitating them, in form of a complex with cholesterol or sytosterol, from an alcoholic extract of the vegetal material and by partitioning the precipitate between an apolar solvent, which subtracts the complexing agent and a polar solvent in which saponins are soluble.

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Rome, Italy

Orlando Ghirardi