Tel Aviv University

Nemis Technologies Ag

Ori Green

Doron Shabat

Nir Hananya

Tal Eilon

Ronit Satchi-Fainaro

Urs P Spitz

Lukas Wick

Ronit Satchi-fainaro

Michal Eli Roth-Konforti

Raffael Vorberg

Riccardo Cribiu

Zuzana Babjakovà

Chunyan Yao

Julian Ihssen

The present invention provides dioxetane-based chemiluminescence probes, more specifically fluorophore-tethered dioxetane-based chemiluminescence probes and compositions thereof. The chemiluminescence probes disclosed are useful for both diagnostics and in vivo imaging.

Chemiluminescent probes for diagnostics and in vivo imaging

Dioxetane compounds represented by Formula I below, and methods of using the dioxetane compounds in the detection of presence or absence, quantification, and identification of microorganisms including bacteria, bacterial fragments (e.g., LPS, endotoxin), viruses, and fungi by means of chemiluminescence. 

Dioxetane compounds and their use for the detection of microorganisms

The present invention provides turn-ON dioxetane-based chemiluminescence probes based on the Schapp's adamantylidene-dioxetane probe, which emit light in the near-infrared (NIR) region and are therefore useful for in vivo imaging, as well as compositions and uses thereof.

Near-infrared chemiluminescent probes for in-vivo imaging

Dioxetane-based chemiluminescence probes, more specifically fluorophore-tethered dioxetane-based chemiluminescence probes and &#x3c0;* acceptor group-containing dioxetane based chemiluminescence probes can be included in compositions. The chemiluminescence probes are useful for both diagnostics and in vivo imaging.

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Tel Aviv, Israel

Ori Green