The General Hospital Corporation

Cambridge Polymer Group, Inc.

Massachusetts General Hospital Corporation

Massachusetts Institute of Technology

Zimmer Gmbh

Other

The General Hosital Corporation

The General Hospital Corporation D/b/a Massachusetts General Hospital

Orhun K Muratoglu

Stephen H Spiegelberg

Ebru Oral

Gareth H McKinley

Harry E Rubash

Edward W Merrill

William H Harris

Murali Jasty

Charles R Bragdon

Daniel O O'Connor

Premnath Venugopalan

Henrik Malchau

Andrew Freiberg

Kartik Mangudi Varadarajan

Thomas Zumbrunn

Edward T Kopesky

Jeremy V Suhardi

Hatice Bodugoz-Senturk

Niels Alexander Abt

Jeffrey W Ruberti

Guoan Li

Gavin Braithwaite

Jeeyoung Choi

Michael Patrick Duffy

Steven Charlebois

Brian H Thomas

Donald L Yakimicki

Gavin J C Braithwaite

James Mason

Ayse Bakar Atici

Bayen Lee Miller

Chhavi Gupta

Ali Eren Atici

Gareth H Mckinley

H Massachusetts Gen Hospital Bodugoz-Senturk

Gavin JC Braithwaite

Therapeutic polymeric materials, therapeutic polymeric materials containing medical implants and methods for making the same, and related materials are described. Methods of making medical implants containing additives/antibiotics, therapeutic polymers, and materials used therewith also are described. Methods of spatially controlling additive/antibiotic concentrations, non-homogenous distribution of therapeutic agents in polymeric materials and therapeutic medical implants containing layered constructs of polymeric materials are provided. Therapeutic medical implants containing incorporated therapeutic agents in the polymeric materials, for example, antibiotics into polymeric total joint implants, are useful for delivery of the therapeutic agents into the surrounding mediums.

Methods of making therapeutic polymeric material

This present invention relates to drug eluting polymers, including novel biodegradable drug eluting polymers, which are added to the surface of a medical device to treat device associated complications and to deliver drug locally around the device. Methods of making polymers, for example, drug-eluting polymers, polymer compositions, and materials used therewith also are provided. The drug eluting polymers are obtained from the polymerization of macromonomers made of a connecting moiety, a biodegradable moiety and a cross-linkable moiety that are liquids at a temperature of 10° C. to 40° C.

Drug eluting polymer composed of biodegradable polymers applied to surface of medical device

The inventions provide methods of manufacturing peroxide cross-linked and high temperature melted polymeric material, for example ultra-high molecular weight polyethylene (UHMWPE) containing vitamin E, total joint implants with high wear resistance, high oxidation resistance, and very low concentration of residual by-products, as well as products made thereby.

Di-cumyl peroxide crosslinking of UHMWPE

The present invention relates to methods for making wear and oxidation resistant polymeric materials by high temperature melting. The invention also provides methods of making medical implants containing cross-linked antioxidant-containing tough and ductile polymers and materials used therewith also are provided.

Methods of making a layered consolidated UHMWPE for use as a medical implant, and products made by the methods

Methods of making crosslinked polymeric materials and crosslinked interlocked hybrid polymeric materials using photoinitiator, antioxidant, additive, and photoirradiation of polymeric blend and/or interlocked hybrid materials are provided. Methods of spatially controlling macroscopic properties and morphology of polymeric materials, and products made by the methods also are provided.

UV-initiated reactions in polymeric materials

Methods of making oxidation and wear resistant polymeric materials using peroxide cross-linking and high temperature melting process are disclosed. A multiple step procedure for enabling the manufacturing of such material without size limitations is also disclosed.

Peroxide cross-linking and high temperature melting

Methods of making a layered consolidated UHMWPE comprising a pharmaceutical compound

Systems and methods of protecting allograft against radiation damage are disclosed. Systems and methods of incorporating additives such as radioprotectants into allograft tissue are also disclosed. The systems and methods comprise providing an allograft; cleaning the allograft; contacting the allograft with at least one radioprotectant, thereby obtaining a radioprotectant-doped allograft; contacting the radioprotectant-doped allograft with a supercritical fluid, thereby obtaining a radioprotectant doped and homogenized allograft.

Systems and methods of radioprotection of allografts

The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.

Methods for making oxidation resistant polymeric material

The invention provides creep resistant, lubricious and tough PVA-PAAm-hydrogels, creep resistant, lubricious, tough PVA-PAAm-hydrogel-containing compositions, and methods of making the same. The invention also provides methods of implanting or administering the creep resistant, lubricious and tough PVA-PAAm-hydrogels, or the PVA-PAAm-hydrogel-containing compositions to treat a subject in need. Methods of cross-linking pre-solidified or pre-gelled hydrogel particles and making cross-linked PVA-PAAm-hydrogels, and cross-linked PVA-PAAm-hydrogel-containing compositions also are disclosed herein.

PVA hydrogels having improved creep resistance, lubricity, and toughness

Femoral heads, mobile inserts, acetabular components, and modular junctions for orthopedic implants, e.g., hip replacement implants, and methods of using femoral heads, mobile inserts, acetabular components, and modular junctions for orthopedic implants are provided. Prosthetic femoral heads, mobile inserts, and acetabular components are provided that can alleviate soft tissue impingement, reduce implant wear, and/or reduce frictional torque. Modular junctions are provided that can minimize the incidence of loosening and micromotion that can occur at modular junctions of orthopedic implants.

Femoral heads, mobile inserts, acetabular components, and modular junctions for orthopedic implants and methods of using femoral heads, mobile insets, acetabular components, and modular junctions for orthopedic implants

The invention provides creep resistant, highly lubricious, tough and ionic hydrogels, creep resistant, lubricious, tough ionic hydrogel-containing compositions, and methods of making the same. The invention also provides methods of implanting or administering the creep resistant, highly lubricious, tough and ionic hydrogels including ionic PVA-hydrogels, ionic PVA-PAAMPS-hydrogels, or the ionic hydrogel-containing compositions to treat a subject in need. Methods of cross-linking pre-solidified or pre-gelled ionic hydrogels and making cross-linked ionic hydrogels and cross-linked ionic hydrogel-containing compositions also are disclosed herein.

Creep resistant, highly lubricious, tough, and ionic hydrogels including PVA-PAAMPS hydrogels

Methods of making a wear and oxidation resistant medical implant are disclosed.

Antioxidant-stabilized joint implants

The present invention relates to methods for making cross-linked oxidation-resistant polymeric materials and preventing or minimizing in vivo elution of antioxidant from the antioxidant-containing polymeric materials. The invention also provides methods of doping polymeric materials with a spatial control of cross-linking and antioxidant distribution, for example, vitamin E (&#x3b1;-Tocopherol), and methods for extraction/elution of antioxidants, for example, vitamin E (&#x3b1;-tocopherol), from surface regions of antioxidant-containing polymeric materials, and materials used therewith also are provided.

Methods for making oxidation-resistant cross-linked polymeric materials

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Cambridge, MA, United States of America

Orhun K Muratoglu