Ono Pharmaceutical Co., Ltd.

Other

Orest Taras Macina

Dingwei Tim Yu

Yoshitaka Konishi

Sung J Lee

Kigen Kondo

Jagadish C Sircar

Ila Sircar

Christopher Mark Riviello

Manton Rodgers Frierson

Masafumi Sugitani

Tamara A Miskowski

Disclosed is a novel class of thiazole, thiadiazole, and oxadiazole compounds which are substituted at their nuclear carbons by aromatic moieties. These compounds exhibit antifungal activity against a variety of fungi including strains which have proven to be resistant to treatment with known antifungal agents such as Fluconazole.

Class of thiomorpholino substituted thiazoles

Class of piperazino substituted thiazoles

Oxadiazole antifungal agents

Diaryl substituted thiazoles useful in the treatment of fungal infections

The compounds of the formula: ##STR1## wherein Y is bond or alkylene;

Heterocyclic compounds

The compounds of the formula: ##STR1## wherein ring ##STR2## is a hetero ring containing nitrogen atom, optionally selected from ##STR3## n is 0-2; Y is bond or alkylene;

Fused pyrimidines and pyriazines as pharmaceutical compounds

A 4-aminopyrimidine of the formula (I): ##STR1## wherein A is a bond, C1-4 alkylene or C1-4 oxyalkylene;

4-aminopyrimidine derivatives

The compounds of the formula: ##STR1## wherein R.sup.1, Y, A, Z, CyB, R.sup.3, R.sup.4, n and m are described in the specification and claims. and acid addition salts thereof, salts thereof, and hydrates thereof; have inhibitory effect on cGMP-PDE, and additionally on TXA.sub.2 synthetase.

4-aminoquinazoline derivatives

The compounds of the formula: ##STR1## wherein R.sup.1, Y, A, R.sup.4, n, Z, CyB, R.sup.3, and m are defined in the specification.

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Pittsburgh, PA, United States of America

Orest Taras Macina