Atrin Pharmaceuticals LLC

Oren Gilad

Henry Joseph Breslin

Gerhard Sperl

Laura Butler

Eric J Brown

The disclosure is directed to compounds and compositions that inhibit Ataxia Telengiectasia And Rad3-Related (ATR) Protein Kinase and methods of their use.

Ataxia telengiectasia and rad3-related (ATR) inhibitors and methods of their use

Macrocyclic compounds having the structure of Formula (A), or pharmaceutically acceptable salts thereof, are provided: wherein R, R, R, Rand Rare defined herein. Also provided are pharmaceutical compositions comprising the macrocyclic compound and methods for treating cancer in a patient comprising administering to the patient the macrocyclic compound.

Ataxia telengiectasia and Rad3-related (ATR) protein kinase inhibitors

Macrocyclic compounds having the structure of Formula (A), or pharmaceutically acceptable salts thereof, are provided, wherein R, R, R, Rand Rare defined herein. Also provided are pharmaceutical compositions comprising the macrocyclic compound and methods for treating cancer in a patient comprising administering to the patient the macrocyclic compound.

Macrocyclic compounds having the structure of Formula (A), or pharmaceutically acceptable salts thereof, are provided, wherein R, R, Z, Z, v, T, L, R, Rand Rare defined herein. Also provided are pharmaceutical compositions comprising the macrocyclic compound and methods for treating cancer in a patient comprising administering to the patient the macrocyclic compound.

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Ambler, PA, United States of America

Oren Gilad