Endospan Ltd.

Or Zigelboim

Yaniv Marmur

Alon Shalev

Nir Shalom Nae

An elongate delivery shaft assembly () includes an outer covering shaft () and an inner support shaft (). When the delivery shaft assembly () is unconstrained and a stent-graft () is removably constrained in a radially-compressed delivery state along a distal end portion () of the delivery shaft assembly (), radially between the outer covering shaft () and the inner support shaft (): (a) the delivery shaft assembly () is shaped so as to define a self-orienting portion (), which (i) is shaped so as to define at least proximal and distal curved portions (A,B), the proximal curved portion (A) disposed more proximal than the distal curved portion (B), and (ii) at least one point of inflection () on a central longitudinal axis () of the delivery shaft assembly () longitudinally between the proximal and the distal curved portions (A,B), and (b) respective smallest radii of curvature of the proximal and the distal curved portions (A,B), measured at the central longitudinal axis (), are each between 2.5 and 12 cm.

Self-orienting endovascular delivery system

An endovascular system includes an elongate delivery shaft assembly, which, when a stent-graft is removably constrained in a radially-compressed delivery state along a distal end portion of the delivery shaft assembly, is shaped so as to define a self-orienting portion, which is shaped so as to define (a) at least proximal and distal curved portions, the proximal curved portion disposed more proximal than the distal curved portion, and (b) at least one point of inflection on a central longitudinal axis of the delivery shaft assembly longitudinally between the proximal and the distal curved portions. Upon positioning of a distal tip of the system near a bifurcation of a brachiocephalic artery from an aortic arch, the self-orienting portion automatically rotationally orients itself in the aortic arch to a rotational orientation in which an inferior lateral opening of the stent-graft faces upstream in the aortic arch. Other embodiments are also described.

A method for treating a subject includes providing an endovascular system that includes a stent-graft and an elongate delivery shaft assembly. When the delivery shaft assembly is unconstrained and the stent-graft is removably constrained along a distal end portion of the delivery shaft assembly, the delivery shaft assembly is shaped so as to define a self-orienting portion, which is shaped so as to define at least proximal and distal curved portions. The delivery shaft assembly is transvascularly introduced into a descending aorta of the subject and a distal end of the delivery shaft assembly is advanced to an aortic arch, such that the self-orienting portion assumes a desired rotational orientation in the aortic arch. While the distal end of the delivery shaft assembly is positioned in the aortic arch, the stent-graft is released from the distal end portion of the delivery shaft assembly. Other embodiments are also described.

An endovascular prosthesis includes a stent-graft and an external coagulation inducer. The stent-graft includes a first portion of structural strut members and a first portion of a graft member, which, when the endovascular prosthesis is unconstrained in a radially-expanded state, together are shaped so as to define a blood-carrying tubular structure defining a lumen. The external coagulation inducer includes an extra-luminal skirt, which includes a second portion of the structural strut members and a second portion of the graft member, and is configured to assume: (i) when the endovascular prosthesis is removably disposed in a delivery sheath, a radially-compressed delivery state, in which the structural strut members of the first portion do not coincide with the structural stent members of the second portion, and (ii) when the endovascular prosthesis is unconstrained, a radially-expanded state, in which the extra-luminal skirt extends radially outward from an external surface of the stent-graft.

Stent-grafts systems with skirt

A deployment system () includes an inner shaft (), removably disposed in a self-expanding stent-graft (), and shaped so as to define (a) at least one conduit therealong (), which is (i) not coaxial with the inner shaft (), and (ii) shaped so as to define at least first () and second enclosed longitudinal segments (), and (b) a restraining longitudinal portion () that is longitudinally disposed between the first () and second enclosed longitudinal segments (). The deployment system () is configured such that (a) when a restraining wire () thereof is removably disposed in the first () and second enclosed longitudinal segments (), a portion () of the restraining wire () disposed alongside the restraining longitudinal portion () prevents full radial expansion of a longitudinal portion () of the stent-graft () by physically engaging the stent-graft longitudinal portion (), and (b) when the restraining wire () has been withdrawn from at least the first enclosed longitudinal segment (), the restraining wire () does not prevent the full radial expansion of the stent-graft longitudinal portion ().

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Givatayim, Israel

Or Zigelboim