Massachusetts Institute of Technology

Or A Shemesh

Edward Stuart Boyden

Changyang Linghu

Asmamaw T Wassie

Chih-Chieh Yu

Kiryl Piatkevich

Won Min Park

The invention, in some aspects, relates to polypeptide molecules and their encoding nucleic acid molecules and use of such molecules to direct and localize sensor molecules in the soma of cells in which they are expressed. Compositions of the invention may be delivered to cells and subjects and used in methods to determine activity in cells in which they are expressed.

Cell body targeted sensors

The invention, in some aspects, relates to polypeptide molecules and their encoding nucleic acid molecules and use of such molecules to target opsins to the soma of cells in which they are expressed. Compositions of the invention may be delivered to cells and subjects and used in methods to modulate electrical activity of cells in which they are expressed, and for treatment of diseases and conditions in subjects.

Somatic opsins for single cell resolution optogenetics

The invention, in some aspects relates to compositions and methods for imaging biological systems and physiological activity and conditions in cells.

Growing community of inventors

Somerville, MA, United States of America

Or A Shemesh