Eisai Company, Limited

Ono Hideki

Tadashi Sato

Satoru Tanaka

Tsuneo Wakabayashi

Issei Ohtsuka

Toshinobu Kunii

Toshiharu Ohgoh

Kouichiro Ueda

Mayumi Kawase

Kengo Kagei

Novel hydantoin derivatives and salts thereof, the process for the preparation thereof, and medicines containing the same, wherein the hydantoin derivatives are represented by the general formula: ##STR1## wherein X.sub.1 and X.sub.2, which may be the same or different, independently represent a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group; Y represents an oxygen atom or sulfur atom, R.sub.1 and R.sub.2, which may be the same or different, independently represent a hydrogen atom, a lower alkyl group or phenyl group, or both may form a ring with carbon atoms, excluding the case wherein both R.sub.1 and R.sub.2 are hydrogen atom, and n represents 0 or 1. The novel hydantoin derivatives and salts thereof have excellent effects for the treatment of the complications of diabetes mellitus.

Treating complications of diabetes mellitus with hydantoin derivatives

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Aichi, Japan

Ono Hideki