The Brigham and Women's Hospital, Inc.

Massachusetts Institute of Technology

Harvard College

Children's Medical Center Corporation

Seer, Inc.

Columbia University

The Brigham and Women's Hosptial, Inc.

Prognomiq, Inc.

Icahn School of Medicine at Mount Sinai

Omid C Farokhzad

Robert Samuel Langer

Ulrich Von Andrian

Pamela A Basto

Jinjun Shi

Frank Alexis

Matteo Iannacone

Elliott Ashley Moseman

Elena Tonti

Liangfang Zhang

Morteza Mahmoudi

Claudia Corbo

Frank X Gu

Jeffrey Michael Karp

John E Blume

Benjamin A Teply

Aleksandar Filip Radovic-Moreno

Gregory Troiano

Tobias Junt

Xiaoyan Zhao

Michael Figa

Jun Wu

Stephen J Lippard

Rohit Nandkumar Karnik

William Manning

Weiwei Gao

Praveen Kumar Vemula

Craig Stolarczyk

Lyndal Hesterberg

Philip Ma

Sufeng Zhang

Alexander H Slocum, Jr

Stephen E Zale

Jianjun Cheng

Bruce R Zetter

Shanta Dhar

Ira A Tabas

Asim Siddiqui

Daniel Griffith Anderson

Martin J Goldberg

Alexander H Slocum

Bryan Laulicht

Gershon Golomb

Zahi A Fayad

Robert S Langer, Jr

Robert S Langer

Theodore Platt

Abdullah M Syed

Hongwei Xia

Matthew McLean

Marwin Ko

Lili Zhao

Aude Thiriot

Nathaniel R Campbell

Erik Bassett

Pedro M Valencia

William C Manning, Jr

Yingjie Xu

Nagesh Kolishetti

Xiaoding Xu

Xiaoyang Xu

Xueqing Zhang

Nazila Kamaly

Mingming Ma

Xi Zhu

Archana Swami

Carolina Salvador-Morales

Juliana M Chan

Mohammad Ariful Islam

Edward A Fisher

Daniel Hornburg

Damian Harris

Eoin D O'Cearbhaill

Michael N Starnbach

Alireza Khademhosseini

Sangtae Kim

Francois Fay

Robert Langer

Sangyong Jon

Chris Cannizzaro

Liang Guo

Sang Yong Jon

Yanlan Liu

Georg Stary

Won Il Choi

YongTae Kim

Amy Wang

Sunandini Chopra

Willem J Mulder

Gabrielle Beth Fredman

Xue-Qing Zhang

Asim S Siddiqui

Margaret Donovan

Xiaobo Wang

Eric M Pridgen

Suresh Gadde

Zeyu Xiao

Cristian Vilos

Alexander Votruba

The present disclosure provides a system comprising a communication interface and computer for assigning a label to the biomolecule fingerprint, wherein the label corresponds to a biological state. The present disclosure also provides a sensor arrays for detecting biomolecules and methods of use. In some embodiments, the sensor arrays are capable of determining a disease state in a subject.

System and sensor array

Compositions, methods, and systems for analyzing the protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic targets.

Compositions, methods and systems for protein corona analysis and uses thereof

The present invention relates to methods and compositions for specifically modulating the Hippo pathway transcription factor TAZ (WWTR1), as a therapeutic target for inhibiting or preventing liver conditions including the progression of steatosis-to-NASH in a patient.

Therapeutic targets involved in the progression of nonalcoholic steatohepatitis (NASH)

Disclosed herein are compositions and methods for assaying for proteins and nucleic acids, in parallel.

Compositions and methods for assaying proteins and nucleic acids

System and method for protein corona sensor array for early detection of diseases

Disclosed herein are methods and compositions for processing biofluid samples. Some such methods may include obtaining a biofluid sample from a subject having a disease state such as lung cancer. The biofluid sample may be contacted with a nanoparticles to adsorb proteins. The proteins may then be ionized or contacted with a detection reagent. Also disclosed herein are compositions comprising proteins coupled to a nanoparticle upon contact of the nanoparticle with a biofluid sample from a subject having a disease.

Methods of processing a biofluid sample

Cationic polymers are provided for delivering anionic active agents, preferably in the form or nanoparticles and other nanostructures. The polymer can be a polycation homopolymer or a copolymer containing a polycation block. The polycations and polycation containing polymers can contain dicarboxylic acid ester units and units of (α-amino acid)-α,ω-alkylene diester units. The nanoparticles can contain high loadings of anionic active agents, with sustained release of the active agents. Methods of making the polycations and polycation containing polymers are provided. Methods of making the nanoparticles and formulating them for administration to an individual in need thereof are also provided.

Cationic materials and formulations for drug delivery

Provided is a nanoparticle comprising a pH-responsive polymer, a pH-insensitive polymer and a payload molecule. The nanoparticle can act as a system for delivery of the payload that releases the payload in a pH sensitive manner.

Nanoparticles with pH triggered drug release

Self-assembled gel compositions including a gelator, e.g., an enzyme-cleavable gelator, e.g., having a molecular weight of 2500 or less, are described. The self-assembled gel compositions can encapsulate one or more agents. Methods of making the self-assembled gel compositions, and methods of drug delivery using the self-assembled gel compositions are also described.

Nanostructured gels capable of controlled release of encapsulated agents

Disclosed herein are biomarkers associated with a disease state such as lung cancer, and methods of discovering or using biomarkers. Also disclosed herein are classifiers built on biomarkers and methods of detecting the disease state in samples from subjects. The method may include obtaining a data set that includes protein information from a biofluid sample, and may involve using a classifier to identify the sample as indicative of a healthy state, a disease state, or a comorbidity.

Lung biomarkers and methods of use thereof

The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or in B cells, in some embodiments, comprising at least one immunomodulatory agent, and optionally comprising at least one targeting moiety and optionally at least one immunostimulatory agent. The invention provides pharmaceutical compositions comprising inventive vaccine nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive vaccine nanocarriers and pharmaceutical compositions thereof. The invention provides methods of prophylaxis and/or treatment of diseases, disorders, and conditions comprising administering at least one inventive vaccine nanocarrier to a subject in need thereof.

Vaccine nanotechnology

Growing community of inventors

Chestnut Hill, MA, United States of America

Omid C Farokhzad