Spectrum Dynamics LLC

Biosensors International Group, Ltd.

Spectrum Dynamics Medical Limited

Omer Ziv

Shlomo Ben-Haim

Benny Rousso

Eli Dichterman

Michael Nagler

Ran Ravhon

Yoel Zilberstein

Haim Zvi Melman

Nathaniel Roth

Dalia Dickman

Simona Ben-Haim

Zohar Bronshtine

Shankar Vallabhajosula

Daniel Berman

Ziv Popper

Nir Weissberg

Leonid Gluhovsky

Yoel Zilberstien

A method for reconstructing a radioactive emission image of an overall volume having first and second volumetric regions, each volumetric region having respectively independent dynamic characteristics. The method comprises the following steps: a) obtaining radioactive emissions from the overall volume, including the volumetric regions, b) reconstructing an initial radioactive emission image of the volumetric region according to the radioactive emissions, c) segmenting the initial radioactive emission image to delineate the first and second volumetric regions, and d) separately reconstructing the first and the second volumetric regions according to the respectively independent dynamic characteristics.

Gating with anatomically varying durations

A method for predefining a set of radioactive-emission measurement views, for radioactive-emission imaging after an administration of a radiopharmaceutical, the method being tailored to a specific body structure and optimized with respect to the information gained about the body structure and based on modeling body-structure, based on its geometry and anatomical constraints, which limit accessibility to the body structure.

Radioactive-emission-measurement optimization to specific body structures

A method for stabilizing the reconstruction of an imaged volume is presented. The method includes the steps of performing an analysis of the reliability of reconstruction of a radioactive-emission density distribution of the volume from radiation detected over a specified set of views, and defining modifications to the reconstruction process and/or data collection process to improve the reliability of reconstruction, in accordance with the analysis.

Reconstruction stabilizer and active vision

Radioimaging using low dose isotope

A method of radioactive-emission-measurement. The method comprises providing a camera for the detection of single emissions, which defines proximal and distal ends. The camera is configured for enabling a reconstruction of a volumetric image having a line spread function of less than 7 mm Full Width Half Maximum (FWHM) when given a substantially line source of radioactive emission, with an activity of 5 mCi, within a region-of-interest volume, at a distance of at least 100 mm from said distal end, with air being substantially the only operating medium. The method further comprises detecting at least 1 of every 5000 photons, emitted from at least one radioactive-emission source, located within a certain region-of-interest volume, using the camera, and reconstructing a volumetric radioactive-emission image from the detected photons.

System and method for radioactive emission measurement

Radioimaging methods, devices and radiopharmaceuticals therefor.

Radioimaging

Systems, methods, and probes are provided for functional imaging by radioactive-emission-measurements, specific to body structures, such as the prostate, the esophagus, the cervix, the uterus, the ovaries, the heart, the breast, the brain, and the whole body, and other body structures. The nuclear imaging may be performed alone, or together with structural imaging, for example, by x-rays, ultrasound, or MRI. Preferably, the radioactive-emission-measuring probes include detectors, which are adapted for individual motions with respect to the probe housings, to generate views from different orientations and to change their view orientations. These motions are optimized with respect to functional information gained about the body structure, by identifying preferred sets of views for measurements, based on models of the body structures and information theoretic measures. A second iteration, for identifying preferred sets of views for measurements of a portion of a body structure, based on models of a location of a pathology that has been identified, makes it possible, in effect, to zoom in on a suspected pathology. The systems are preprogrammed to provide these motions automatically.

A method of imaging, including receiving radioactive radiation from a body; reconstructing a 3D SPECT image of a distribution of radiation in at least one voxel of said body; and reconstructing a dynamic change in radiation in said voxel, as an updated image, at a rate of faster than one change per 5 minutes, wherein said reconstructed image is a clinically useful image including a resolution of 10 mm or better for a voxel volume of at least 5 cm in diameter and a contrast to background ratio of radiation of at least 2:1.

A method of reconstruction of a radioactive emission image. The method comprises providing a first system of voxels for a region of interest, obtaining radioactive-emission data from the region of interest, performing a first reconstruction, based on the radioactive-emission data and the first system of voxels, to obtain a first image, correcting the first system of voxels, by aligning voxel boundaries with object boundaries, based on the first image; thus obtaining a second system of voxels, and performing a second reconstruction, based on the radioactive-emission data and the second system of voxels, thus obtaining a second image.

Dynamic spect camera

A dynamic SPECT camera is provided, comprising, a plurality of single-pixel detectors, a timing mechanism, in communication with each single-pixel detector, configured for enabling time-binning of the radioactive emissions impinging upon each single-pixel detector to time periods not greater than substantially 30 seconds, and a position-tracker, configured for providing information on the position and orientation of each detecting unit, with respect to the overall structure, substantially at all times, during the individual motion, the dynamic SPECT camera being configured for acquiring a tomographic reconstruction image of a region of interest of about 15&#xd7;15&#xd7;15 cubic centimeters, during an acquisition time of 30 seconds, at a spatial resolution of at least 10&#xd7;10&#xd7;10 cubic millimeter. The dynamic camera is configured for very short damping time, and may further acquire images in a stationary mode, with no motion. It is further configured for time binning at dynamically varying time-bin lengths, dynamically determining a spectral energy bin for each detecting unit, and employing an anatomic construction of voxels in the imaging and reconstruction.

Growing community of inventors

Rechovot, Israel

Omer Ziv