Memorial Sloan Kettering Cancer Center

Cornell University

Omer Aras

Babak Mehrara

Jason Gardenier

Ira Savetsky

Richard Ting

Feifei An

Nandi Chen

A compound according to Formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, wherein Xand Xare each independentlyF orF; Rand Rare each independently alkyl, amine, perfluoroalkyl, alkenyl, alkynyl, aryl, or aralkenyl; and Ris H, halo, alkyl, alkyl ester, alkenyl, alkynyl, aryl, or aralkenyl; or wherein: Rand Ror Rand Rjoin to form a 6-membered cycloalkyl or heterocyclyl; or Rand R, Rand R, or R, R, and Rjoin to form a substituted or unsubstituted polycyclic ring, wherein the polycyclic ring comprises fused cycloalkyl, heterocycloalkyl, aryl, or heteroaryl rings.

One-step, fast, 18F-19F isotopic exchange radiolabeling of difluoro-dioxaborinins and use of such compounds in treatment

Provided are pharmaceutical compositions and methods of treating or preventing edema, using an anti-T cell agent, an anti-TGF-β1 agent, or an anti-angiotensin agent, preferably a combination of at least two such agents. The pharmaceutical compositions can be formulated for systemic or local administration, and are preferably administered topically.

Compositions and methods for treatment of edema

Provided are pharmaceutical compositions and methods of treating or preventing edema, using an anti-T cell agent, an anti-TGF-&#x3b2;1 agent, or an anti-angiotensin agent, preferably a combination of at least two such agents. The pharmaceutical compositions can be formulated for systemic or local administration, and are preferably administered topically.

Growing community of inventors

New York, NY, United States of America

Omer Aras