Arizona State University

Arizona Board of Regents, a Body Corporate

Omar Khdour

Sidney M Hecht

Sandipan Roy Chowdhury

Arnaud Chevalier

Indrajit Bandyopadhyay

Yanmin Zhang

Poulami Talukder

Nishant P Visavadiya

Sidney Hecht

Manikandadas Mathilakathu Madathil

Pablo Arce

Sriloy Dey

Yana Chen

Xiaoqing Cai

Jun Liu

Jose I Armendariz Guajardo

Mohammad Alam

Jun Lu

Indrajit Bandyopadhay

Jeffrey Armstrong

The invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein Rhas any of the values described in the specification, as well as compositions comprising a compound of formula (I). The compounds are useful as cytoprotective agents.

Mitochondrial therapeutic agents

The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables R, R, R, R, subscript m and n, have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Therapeutic compounds

The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables R, R, Rand Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions. 

Substituted pyrimidine compounds as multifunctional radical quenchers and their uses

The present invention relates to the use of prodrugs susceptible to nitroreductase (NTR) activation. In particular, provided herein are mitochondria-targeting prodrug compounds and probes, including profluorescent near-infrared (NIR) probes and non-fluorescent prodrugs, as well as to methods of using said prodrug compounds and probes for imaging mitochondria and for mitochondria-specific delivery of therapeutic agents.

Prodrug and profluorescent compounds for selective mitochondrial imaging and therapeutic targeting

The invention provides compounds formula (I) and salts thereof:  wherein R, R, R, Rand Y have any of the values defined in the specification. The compounds are useful for treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.

Substituted phenothiazines as mitochondrial agents

The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables R, R, R, R, subscipt m and n, have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

The present invention relates to the use of prodrugs susceptible to nitroreductase (NTR) activation. In particular, provided herein are mitochondria-targeting prodrug compounds and probes, including profluore scent near-infrared (NIR) probes and non-fluorescent prodrugs, as well as to methods of using said prodrug compounds and probes for imaging mitochondria and for mitochondria-specific delivery of therapeutic agents.

The present disclosure provides phenothiazine derivative compounds and salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.

Compounds of formula (I) and salts are disclosed. Also disclosed are isotopes of compounds of formula I of the salts thereof. Pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods using a compound of formula I are disclosed.

The invention provides a compound of formula (I): [insert formula (I)] wherein X, Y, and R-Rhave any of the values defined in the specification, and salts thereof, as well as compositions comprising the compounds or salts. The compounds are useful for treating diseases associated with impaired mitochondrial function in an animal. 

Multifunctional radical quenchers

The present disclosure provides biologically active compounds of formula (I): and pharmaceutically acceptable salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation. 

1H-pyrrolo [2, 3 -B] pyridine derivatives and their use as radical quenchers

The present disclosure provides methods for identifying therapeutic agents that are multifunctional radical quenchers. It also provides compounds of formula: and pharmaceutically acceptable salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.

Multifunctional radical quenchers for the treatment of mitochondrial dysfunction

The present disclosure provides compounds of formula (I): compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.

The present disclosure provides methods for identifying therapeutic agents that are multifunctional radical quenchers. It also provides compounds of formula (I), (II), or (II-A): and pharmaceutically acceptable salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.

The present disclosure provides biologically active compounds of formula (I): and pharmaceutically acceptable salts thereof: compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.

Growing community of inventors

Phoenix, AZ, United States of America

Omar Khdour