United Arab Emirates University

Università Degli Studi Di Perugia

Omar El-Agnaf

Lucilla Parnetti

Paolo Calabresi

The invention describes antibodies having a high affinity for aggregated forms of &#x3b1;-synuclein and a low affinity for monomeric forms of &#x3b1;-synuclein. The antibodies are useful in the diagnosis of neurodegenerative diseases.

Alpha-synuclein antibodies and uses thereof

The present invention relates to method of identifying whether or not an individual has Parkinson's disease (PD). In particular, the invention relates to a method for identifying whether or not an individual has PD as opposed to another neurodegenerative disease. The method of the invention comprises measuring the concentration of &#x3b1;-synuclein (&#x3b1;-syn) and the concentration of unphosphorylated tau (tau) and/or phosphorylated tau (p-tau) in a cerebrospinal fluid sample taken from an individual. The method also comprises calculating the ratio of the concentration of tau and/or p-tau to the concentration of &#x3b1;-syn, and thereby determining whether or not the individual has PD.

Method of identifying whether or not an individual has Parkinson's Disease rather than another neurodegenerative disease

The invention provides an agent comprising an amino acid sequence for use in a method of diagnosis of a synucleinopathic disease.

Growing community of inventors

Al Ain, United Arab Emirates

Omar El-Agnaf