The Scripps Research Institute

Taurus Biosciences, LLC

Fabrus, Inc.

Omar A Bazirgan

Vaughn V Smider

Hongyuan Helen Mao

Peter G Schultz

Yong Zhang

Miguel De Los Rios

Helen Hongyuan Mao

Tyson Chase

Byeong Doo Song

James Graziano

Feng Wang

Vaughn Smider

The present disclosure provides humanized antibodies, including antibodies comprising an ultralong CDR3 and uses thereof.

Humanized antibodies with ultralong complementary determining regions

Disclosed herein are immunoglobulin constructs comprising at least one immunoglobulin domain or fragment thereof; and a therapeutic polypeptide or derivative or variant thereof attached to or inserted into said immunoglobulin domain. Also provided are immunoglobulin constructs comprising a mammalian immunoglobulin heavy chain comprising at least a portion of a knob domain in the complementarity-determining region 3 (CDR3H) or fragment thereof; and a therapeutic polypeptide attached to or inserted into said knob domain of the CDR3H. Also provided are immunoglobulin constructs comprising a mammalian immunoglobulin heavy chain comprising at least a portion of a stalk domain in the complementarity-determining region 3 (CDR3H) or fragment thereof; and a therapeutic polypeptide attached to or inserted into said stalk domain of the CDR3H. Also described herein are methods and compositions comprising the immunoglobulin constructs described herein for treatment and prevention of a disease or condition in a subject.

Ultralong complementarity determining regions and uses thereof

Methods for making a combinatorial antibody library from human germline segments are provided. Also provided are libraries of nucleic acid molecules compiled from germline segments encoding VL chains and libraries of nucleic acid molecules encoding VH chains, and resulting antibody libraries. The libraries are provided as addressable libraries. Methods for screening antibody libraries against a target protein antigen, and the identified or selected antibodies are provided.

Combinatorial antibody libraries and uses thereof

Humanized antibodies

Growing community of inventors

San Diego, CA, United States of America

Omar A Bazirgan