Council of Scientific and Industrial Research

Om Parkash Suri

Naresh Kumar Satti

Krishan Avtar Suri

Ghulam Nabi Qazi

Kasturi Lal Bedi

Bal Krishan Chandan

Bishan Datt Gupta

Rakesh Kamal Johri

Vikram Bhardwaj

Bal Krishan Kapahi

Sukhdev Swami Handa

Anamika Khajuria

Subhash Chander Sharma

Bupinder Singh Jaggi

Vishwa Nath Gupta

Ashok Kumar Tikoo

Manoj Kumar Tikoo

Ajit Kumar Saxena

Gulam Nabi Qazi

Ravi Kant Khajuria

Bupinder Singh

Surjit Singh

Sheikh Tasaduq Abdullah

Neelam Sharma

Inshad Ali Khan

Rakesh Maurya

Vijeshwar Verma

Dilip Manikrao Mondhe

Ashwani Kumar

Kuldeep Singh

Anpurna Kaul

Kanaya Lal Dhar

Gurdarshan Singh

Devinder Kumar Gupta

Lila Ram Manahas

Satish Chander Puri

Bal Krishnan Kapahi

Geeta Handa

Anil Prabhakar

Vijay Kumar Sharma

Shankar Lal

Jyotsna Suri

V N Gupta

Madalsa Bargotra

Sheikh Tasaduq Absullah

Satinder Mohan Jain

Musarat Amina

Bhupinder Singh

Sarang Bani

Usha Zutshi

Swadesh Malhotra

Kuldip Kumar Gupta

The present invention relates to a synergistic formulation comprising trans-tetracos-15-enoic acid (t-TCA) and andrographolide (AP) in the ratio ranging between 1:7 to 7:1 (w/w), useful in hepatoprotection; and a process for the preparation of a synergistic formulation comprising trans-tetracos-15-enoic acid (t-TCA) and andrographolide (AP) useful in hepatoprotection, said process comprising steps of grounding the particles of the t-TCA and AP into fine particles, mixing the fine particles in ratio ranging between 1:7 to 7:1 (w/w), and grinding the mixture to obtain formulation, and also, a method of hepatoprotection of a subject using the synergistic formulation comprising trans-tetracos-15-enoic acid (t-TCA) and andrographolide (AP), said method comprising the steps of administering the formulation to the subject.

Synergistic hepatoprotective composition and a method thereof

The present invention relates to a bioenhancing/bioavailability-facilitating composition comprising:

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The present invention provides a method for treating and/or preventing hepatic disease conditions in a subject mammals including human beings, said method comprising the steps of administering to the mammal an effective dosage of composition comprising 2'-p-Hydroxy benzoyl mussaenosidic acid from plantoptionally as individual or in combination with one or more pharmaceutically additives.

Hepatoprotective activity of 2'-p-hydroxybenzoylmussaenosidic acid

The present invention relates to a pharmaceutical composition comprising a bioactive constituent trans-tetracos-15-enoic acid and a process for the isolation of tetracos-15-enoic acid from the plantalong with a method of treatment for hepatotoxicity.

Pharmaceutical composition and process for isolation of trans-tetracos-15-enoic acid and method of treatment for hepatotoxicity

The present invention relates to the use of bioenhancers to decrease the resistance of microbial strains to anti-infective such an antibiotics and antifungals by potentiating the activities of anti-infective. This may be useful to reduce resistance in bacteria and yeast to aid in the treatment of certain infections and disease and to lower the concentration of antiinfectives necessary to inhibit the growth of microbial strains.

Use of herbal agents for potentiation of bioefficacy of anti infectives

The present invention relates to a composition useful for hepatocurative effect against CYP 450 bio-activation hepatotoxicity induced by drugs, said composition comprising an extract fromand optionally pharmaceutically acceptable additives and method of treating drug induced hepatotoxicity.

A process of isolation of pure Acteoside of high hepatoprotection from plant, said process comprising steps of drying aerial parts of the plant, grounding the dried parts into powder, percolating the powder with water or ethanol for 3-4 times to obtain an extract, filtering the extract for clearing of suspended particles to obtain supernatant, drying the supernatant at about 45 to 55&#xb0; C. to obtain a residue, fractionating the residue with chloroform, ethyl acetate, and butanol successively, subjecting butanol fraction to adsorption chromatography of SiOafter adding methanol to the fraction, charging the adsorbed fraction to glass column, eluting the column with solvents of increasing polarity of methanol:chloroform to obtain further fractions and repeating the process one more time, subjecting the fractions to column chromatography to obtain fractions, concentrating the fractions under reduced pressure to obtain acteoside as residue; and a method of effectively hepatoprotecting a subject using pure Acteoside from plant, said method comprising steps of administering appropriate low-dose of the acteoside to the subject.

Hepatoprotective agent of plant origin and a process thereof

The present invention relates to a synergistic hepatoprotective pharmaceutical composition comprising an effective amount of trans-tetracos-15-enoic acid (TCA) and Apocynin (APO), the present invention also relates to a method of treatment for hepatotoxicity in mammals and humans.

Synergistic composition of trans-tetracos-15-enoic acid and Apocynin and method of treatment for hepatotoxicity

The present invention relates to a process for the preparation of trans-alkenoic acids of general formula CH&#x2014;(CH)n&#x2014;CH&#x2550;(CH)mCOH where n=4 to 9 m=8 to 16. More particularly, the present invention relates to a process for the preparation of trans-tetracos-15-enoic acid, which is a bioactive constituent possessing dose-related hepatoprotective activity. The present invention also relates to the use thereof for hepatoprotection.

Process for the synthesis of trans-alkenoic acids, use thereof

The present invention relates to the use of dihalomethanes as reagents for the preparation of Topotecan&lcub;4-(S)-10(dimethylamino)-methyl-4-ethyl 4,9 dihydroxyl-H-pyrano&lsqb;3&prime;4&prime;:6,7&rsqb;indolizino-&lsqb;1,2-b&rsqb;quinoline-3,14(4H,12H)dione&rcub; from 10-hydroxycamptothecin. The invention discloses the rationale use of dichloromethane under solid-liquid phase transfer catalysis, which can behave both as solvent and a reactant when it serves as a source for C-1 unit for amino-alkylation of 10-hydroxy-4-(S)camptothecin.

Process for preparing Topotecan from 10-hydroxy-4-(S) camptothecin

Pharmaceutical composition and a method useful for treating immunodeficiency in animals or human beings, said composition comprising effective amount of the extract obtained from any part of plant either as such or its individual constituents singly or in composition with each other, optionally associated with pharmaceutically acceptable additives.

Pharmaceutical composition comprising extract from plant Cryptolepis buchanani for treating immunodeficiency

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Jammu, India

Om Parkash Suri