Matrix Laboratories Limited

Mylan Laboratories Limited

Om Dutt Tyagi

Purandhar Koilkonda

Ramakoteswara Rao Jetti

Jagan Mohana Chary Tummanapally

Dnyandev Ragho Rane

Purna Chandra Ray

Madhuresh Kumar Sethi

Vellanki Siva Ram Prasad

Saswata Lahiri

Mohan Vamsi Krishna Vadlamudi

Venkata Bala Kishore Sarma Inupakutika

Surya Nageswara Rao Achanta

Daggula Srinivas Reddy

Katukuri Aravind Kumar

Umamaheswar Vasireddy Rao

Mohana Vamsi Krishna Vadlamudi

Dammalapati Ventaka Lakshmi Narasimha Rao

Jakka Devendra Rao

Bhausaheb Chavhan

Vellanki Sivarama Prasad

B A Ramireddy

Prasanth Kumar Barik

Tushar Kumar Srivastava

Arabinda Sahu

Bandi Naga Durga Rao

Disclosed herein an improved process for producing 5-Fluoro-1-(2R,5S)-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine and its pharmaceutical acceptable salts.

Process for producing 5-fluoro-1-(2R, 5S)-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine

The present invention relates to process for the preparation of novel crystalline Desmethylvenlafaxine succinate polymorphic Forms-A, B. The present invention also relates to novel processes for the preparation of 0-Desmethylvenlafaxine succinate polymorphic Forms-(I), (II), (III) and amorphous.

Process for the preparation of O-desmethylvenlafaxine succinate polymorphic forms

Disclosed herein is a novel process for preparing polymorphic Forms of (S)-6-chloro-(cyclopropylethynyl)-1,4-di-hydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one referred as M, I, II, &#x3b2;, and &#x3c9;.

Process for preparing polymorphic forms of (S)-6-chloro-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one

Present invention relates to an improved process for the preparation of Zopiclone and its enantiomerically enriched isomer (Eszopiclone). 6-(5-Chloropyridin-2-yl)-5-hydroxy-7-oxo-5,6-dihydropyrrolo[3,4-b]pyrazine is reacted with 1-chloro-carbonyl-4-methylpiperazine in the presence of alkali earth metal carbonates, hydroxides or oxides in a solvent medium to give Zopiclone. It is reacted with optically active acid in a mixture of water and water miscible organic solvent followed by work up to give Eszopiclone. The present invention also relates to process for the conversion of (R) or (S) Zopiclone to 6-(5-chloropyrid-2-yl)-5-hydroxy-7-oxo-5,6-dihydro-pyrrolo-[3,4-b]-pyrazine of the intermediate which can be converted to racemic Zopiclone.

Preparation of Zopiclone and its enantiomerically enriched isomer

The present invention relates to an improved, process for large scale production of 1-[2-(dimethylamino)-1-(4-phenol)ethyl]cyclohexanol (O-desmethylvenlafaxine) or its pharmaceutically acceptable salts with increased yield and minimal impurities.

Process for producing 1-[2-(dimethylamino)-1-(4-phenol)ethyl]cyclohexanol

An improved process for the preparation of substantially pure valsartan employing suitable reagents such as chelating agent and reaction conditions.

Process for preparing pure valsartan

The present invention relates to a process for the preparation of pure Rabeprazole sulfoxide using the solvent mixture for the extraction steps and this invention further relates to the process for the preparation of amorphous Rabeprazole sodium using pure rabeprazole base in presence of aqueous NaOH and water miscible solvent and adding an anti-solvent.

Process for the preparation of pure rabeprazole

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Hyderabad Telangana, India

Om Dutt Tyagi