The State University of New York

Other

The Research Foundation of Suny

Research Foundation of State of N.y.

Olli P Teronen

Lorne M Golub

Timo Arto Sorsa

Tuula A Salo

Sari Hannele Tikanoja

Nungavarm S Ramamurthy

Hsi-Ming Lee

Timo A Sorsa

The invention relates to methods and test kits for diagnosis of periodontal disease activity in mammals, especially in human. The methods of the invention provide for rapid chair-side diagnosis of periodontitis, peri-implantitis and HIV (&plus;)-infection/AIDS-disease related periodontal diseases. Especially, the methods of the invention provide for rapid chair-side diagnosis of the loss of bone density associated with periodontal diseases.

Diagnostic method for detection of periodontitis or peri-implantitis

The invention is a method of inhibiting the activity of membrane-type matrix metalloproteinase (MT-MMP) in biological systems. Accordingly, the invention permits the treatment of medical conditions in mammals that are characterized by MT-MMP activity, and especially those conditions characterized by excessive MT-MMP activity. The method employs a tetracycline compound, preferably a non-antimicrobial tetracycline, and more preferably 6-demethyl-6-deoxy-4-de(dimethylamino)tetracycline (CMT-,) or 6-&agr;-deoxy-5-hydroxy-4-de(dimethylamino)tetracycline (CMT-,) to inhibit the MT-MMP activity.

Method of inhibiting membrane-type matrix metalloproteinase

The invention relates to methods and test kits for diagnosis of periodontal disease activity in mammals, especially in human. The methods of the invention provide for rapid chair-side diagnosis of periodontitis, peri-implantitis and HIV (+)-infection/AIDS-disease related periodontal diseases. Especially, the methods of the invention provide for rapid chair-side diagnosis of the loss of bone density associated with periodontal diseases.

Tissue-destructive conditions related to excess protemase activity in a biological system are treated or prevented by administering to the system a composition which combines a tetracycline and a bisphosphonate in synergistic proteinase inhibiting amounts.

Combination of bisphosphonate and tetracycline

Tissue-destructive conditions related to excess proteinase activity in a biological system are treated or prevented by administering to the system a composition which combines a tetracycline and a bisphosphonate in synergistic proteinase inhibiting amounts.

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Helsinski, Finland

Olli P Teronen