Centre National De La Recherche Scientifique

University Claude Bernard - Lyon 1

Total Sa

Nanoh

Institut National Des Sciences Appliquees De Lyon

Universitë De Bordeaux

Université Grenoble Alpes

University Claude Bernard Lyon I

The Brigham and Women's Hospital, Inc.

National Institute of Health and Medical Research

Totalenergies Onetech

Centre National De La Recherche Scientifique-Cnrs

Hospices Civils De Lyon

Total Se

Ecole Nationale Superieure De Chimie De Paris

Olivier Tillement

François Lux

Christian Hurtevent

Salima Baraka-Lokmane

John-Richard Ordonez-Varela

Arthur Marais

Pascal Perriat

Fabien Rossetti

Stéphane Roux

Matteo Martini

Mattéo Martini

Jean-Marie Dubois

Yves Fort

Jean-Luc Coll

Sandrine Dufort

Anna Mignot

Andrea Bianchi

Thomas Brichart

Maxime Saint Jean

Pierre Mowat

Florian Lepoivre

Mahmoud Ould-Metidji

Cedric Louis

Annie Commarieu

Antoine Vanlaer

Stéphane Jouenne

Nathalie Mignet

Ross Berbeco

Christophe Marquette

Johanne Seguin

Cédric Louis

Yannick Cremillieux

Fabrice Aubertin

Claire Billotey

François Ghillebaert

Vu-Long Tran

Clélia Mathieu

Geraldine Le Duc

Myleva Dahan

Alexandre Detappe

Gilles Ledoux

Eloise Thomas

Vivek Thakare

Rana Bazzi

Nicolas Crowther

Marc Janier

Mahmoud Ould Metidji

Albert Moussaron

Anatole Collet

Francisco Vasquez Velado

Vu Long Tran

Luc Brient

Stephane Roux

Brice Mutelet

Celine Mandon

Geraldine Leduc

Christophe Alric

Francois Ghillebaert

Francois Lux

Céline Mandon

Lucie Sancey Galliot

Jules Tillement

Denise Bechet

Marie Victor

Géraldine Leduc

Bich-Thuy Doan

Grégory Ramniceanu

Marco Natuzzi

The present invention relates to the field of nanovectors for the delivery of active substances in the body, in particular for the treatment of tumours. In particular, the use of these nanovectors makes it possible to improve the pharmacokinetics of the active substances with a more selective delivery, for example in the tumour tissues.

Nanovectors and uses

Provided herein are nanoparticle compositions (e.g., nanoparticle compositions comprising high atomic number ions) that are useful for imaging diseases in a subject as well as radiosensitizing a disease in a subject (e.g., radiosensitizing a cancer in the subject). Methods of imaging a subject, methods of treating cancer, and processes of preparing the nanoparticle compositions are also provided.

Bismuth-gadolinium nanoparticles

The invention relates to a novel use of ultrafine nanoparticles, of use as a diagnostic, therapeutic or theranostic agent, characterized by their mode of administration via the airways. The invention is also directed toward the applications which follow from this novel mode of administration, in particular for imaging the lungs, and the diagnosis or prognosis of pathological pulmonary conditions. In the therapeutic field, the applications envisioned are those of radiosensitizing or radioactive agents for radiotherapy (and optionally curietherapy), or for neutron therapy, or of agents for PDT (photodynamic therapy), in particular for the treatment of lung tumors.

Ultrafine nanoparticles as multimodal contrast agent

The invention relates to a method for synthesizing ultrasmall silica nanoparticles, useful in particular for diagnostics and/or therapy. More specifically, a method for synthesizing silica nanoparticles, said method comprising the mixing of at least one silane which is negatively charged at physiological pH with at least one silane which is neutral at physiological pH, and/or at least one silane which is positively charged at physiological pH, wherein: &#x2014;the molar ratio A of neutral silane(s) to negatively charged silane(s) is defined as follows: 0&#x2264;A&#x2264;6, &#x2014;the molar ratio B of positively charged silane(s) to negatively charged silane(s) is defined as follows: 0&#x2264;B&#x2264;5, &#x2014;the molar ratio C of neutral and positively charged silanes to negatively charged silane(s) is defined as follows: 0&#x3c;C&#x2264;8. The invention also relates to the obtained ultrasmall silica nanoparticles.

Method for synthesizing silica nanoparticles

The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy. The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRI) and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies. Thus, the nanoparticles according to the invention, with diameter dbetween 1 and 20 nm, each comprise a polyorganosiloxane (POS) matrix including gadolinium cations optionally associated with doping cations; a chelating graft CDTPABA (diethylenetriaminepentaacetic acid bisanhydride) bound to the POS matrix by an &#x2014;Si&#x2014;C&#x2014; covalent bond, and present in sufficient quantity to be able to complex all the gadolinium cations; and optionally another functionalizing graft Gf* bound to the POS matrix by an &#x2014;Si&#x2014;C&#x2014; covalent bond (where Gf* can be derived from a hydrophilic compound (PEG); from a compound having an active ingredient PA1; from a targeting compound; from a luminescent compound (fluorescein). The method for the production of these nanoparticles and the applications thereof in imaging and in therapy also form part of the invention.

Ultrafine nanoparticles comprising a functionalized polyorganosiloxane matrix and including metal complexes; method for obtaining same and uses thereof in medical imaging and/or therapy

A method for the detection and quantification, in a complex aqueous fluid, of additives and water-soluble polymers used in the enhanced recovery of oil and shale gas.

Method for detecting and quantifying additives used in the enhanced recovery of oil and shale gas

A method for detecting and quantifying additives in a complex aqueous fluid, and a method for detecting an inhibitor of mineral deposition or corrosion, injected in a gas or oil well. The invention also relates to a developer solution including a lanthanide and a chelating agent for detecting said additives or inhibitors.

Method and solution for assaying inhibitors in a petroleum fluid containing water

The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy. The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRI) and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies. The method for the production of these nanoparticles and the applications thereof in imaging and in therapy also form part of the invention.

The use, as markers of petroleum products, crude oils, biofuels or lubricants, of rare earth complexes or one of the constituents thereof chosen from rare earth ligands or salts, being capable of forming a rare earth complex after the addition of a developing solution. Preferably, the rare earth complex can be detected by time-resolved fluorescence. Also, a marking method and a method for detecting a rare earth complex as a marker of petroleum products, crude oils, biofuels or lubricants.

Use of rare earth complexes as markers of petroleum products, crude oils, biofuels or lubricants

A method for adjusting, to a pre-determined value, the level of a mineral deposition or corrosion inhibitor injected into a gas or oil well. Using of the time-resolved fluorescence method for detecting and quantifying a mineral deposition or corrosion inhibitor in a fluid from an oil or gas production well.

Method for adjusting the level of inhibitors in an oil or gas well

Novel hybrid nanoparticles, useful for inhibiting or slowing down the formation of sulfur deposits or minerals in a well during the extraction of gas or oil. Specifically, the nanoparticles each include (i) a polyorganosiloxane (POS) matrix; and, optionally as a coating over a lanthanide oxide core, (iii) at least one polymeric scale inhibitor during the extraction of gas or oil. The invention also relates to the method for obtaining the nano-inhibitors and the application of same.

Nano-inhibitors

A copolymer containing a unit including an optionally neutralized styrene sulphonic acid unit and a unit containing at least one optionally neutralized (poly)carboxylic acid unit or a (poly)amido-amine unit, to inhibit or slow the formation of sulphide deposits during the extraction of gas or oil. It also relates to a method to inhibit or slow the formation of sulphide deposits during the extraction of gas or oil, including the injection of a fluid containing the abovementioned copolymer into a wellbore, a subterranean formation or a gas or oil well.

Use of a copolymer made from styrene sulphonic acid to inhibit or slow the formation of sulphide deposits

The present invention relates to the development of tracer fluids, more generally, that of aqueous liquids, intended to be injected under pressure in an oil reservoir, for example from an injection well up to a production well. The object of the invention is to propose a new method of study of a solid medium, i.e. an oil reservoir, by diffusion of a liquid (i.e. injection waters) containing tracers, through said solid medium, which is simple to implement and economical and which remedies the drawbacks of the known tracers for injection waters of oil reservoirs. This method essentially consisting of injecting, in this solid medium, an injection liquid comprising a nanoparticle-based tracer having average dimensions comprised between 20 and 200 nm, detectable by means of one or several S signals at dilutions of less than or equal to 10, adapted to form a stable colloidal suspension in a saline medium, at least a portion of which is constituted of a core and a coating provided with an adjustable hydrophilic-lipophilic balance (HLB) and comprising at least one organic and/or organosilicon component; recovering the liquid having diffused; and analyzing this liquid having diffused to measure the quantity of tracer by detection of the signal or signals S.

Use of nanoparticles for labelling oil field injection waters

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Olivier Tillement