Universitât Bern

Alveolix Technologies Ag

Olivier Thierry Guenat

Janick Stucki

Marcel Aeschlimann

Thomas Geiser

Christophe Léchot

Marcel Felder

Andreas Stucki

Janick Daniel Stucki

A culturing membrane comprising a support provided by a mesh with holes filled with extracellular matrix proteins, as well as a method of producing a culturing membrane made of components found in a basal membrane, comprising the steps of using a mesh having holes; and providing a solution with the components found in the basal membrane on the mesh.

Cell culturing system and method

A cell culturing system includes a docking station, a handling unit, a culturing module and an actuation layer. The culturing module has a culturing well and a culturing membrane separating the culturing well in an apical culturing chamber and a basal culturing chamber. The handling unit removably accommodates the culturing module and the actuation layer. The docking station has a coupling structure for removably holding the handling unit in a predefined position and an actuation feeding channel, wherein, when the handling unit is held by the coupling structure in the predefined position, a first end of the actuation feeding channel is connected to the actuation bore and a second end of the actuation feeding channel is connected to a connector.

A device for in-vitro modelling in-vivo tissues of organs that includes a first body portion with at least one access chamber, a second body portion with at least one culturing chamber, and a culturing membrane dividing the at least one access chamber from the culturing chamber. The device further includes a third body portion with at least one actuation chamber having at least one limitation cavity, and an actuation membrane dividing the at least one culturing chamber from the at least one actuation chamber. With the device, a robust actuation system can be provided that does not depend on the mechanical properties of the actuation membrane material, nor on the pressure, and that allows to mimic three-dimensional deformations of the tissue, in particular of lung alveoli.

Device for in-vitro modelling in-vivo tissues of organs

Growing community of inventors

Bern, Switzerland

Olivier Thierry Guenat