Guerbet

Guerbet S.a.

Centre National De La Recherche Scientifique

Université De Bretagne Occidentale

Olivier Rousseaux

Dominique Meyer

Christian Simonot

Marc Port

Michel Schaefer

Raphaël Tripier

Maryline Beyler

Mariane Le Fur

Olivier Fougère

Claire Corot

Robert Muller

Carmen Burtea

Sarah Catoen

Gwladys Nizou

Isabelle Raynal

Christelle Medina

Anne Bouillot

William Pauly - Batard

Irène Guilbert

Jean Sébastien Raynaud

The present invention relates to novel lipophilic macrocyclic ligands, the complexes thereof, in particular radioactive complexes, and the uses of same in medical imaging and/or in therapy, in particular in interventional radiology.

Lipophilic macrocyclic ligands, complexes thereof, and uses of same

Ligands that are based on the pyclen macrocycle that are reinforced, which are useful for complexing elements such as radioelements and/or elements with magnetic properties.

Reinforced macrocyclic ligands, complexes thereof, and uses of same

A macrocycle compound of general formula (X) in which Yrepresents a C(O)OH group or a group of formula (II) 

Macrocyclic ligands with picolinate group(s), complexes thereof and also medical uses thereof

The present invention relates to compounds, ligands, and/or complexes that are useful in medical imaging and/or in therapy, especially in cancer treatment. The present invention also relates to a pharmaceutical composition comprising said compounds, ligands, and/or complexes that are useful for medical imaging, targeting, and/or treatment of cancers. The present invention also relates to a process for preparing these compounds, ligands, and/or complexes.

Macrocylic ligands with picolinate group(s), complexes thereof and also medical uses thereof

A novel method for preparing nanoparticles for medical imaging, including a metal core, an organic stabilizing layer containing gem-bisphosphonate compounds and at least one hydrophilic biodistribution ligand.

Method for preparing nanoparticles covered with a gem-bisphosphonate stabilizing layer coupled to hydrophilic distribution ligands

The present invention relates to a compound of the following general formula (I): Signal-Linker-Peptide (I) in which Signal is a signal entity; Linker, is absent or is a chemical bond, and Peptide is a peptide having a VCAM-targeting peptide and pharmaceutically acceptable salts thereof. The VCAM-targeting peptide may be X10-X11-X12-X13-X14-X15-X16-X17-X18 (SEQ ID No. 4) with X10 chosen from cysteine and methionine; X11 chosen from methionine and cysteine; X12 chosen from lysine, arginine and alanine; X13 chosen from threonine and serine; X14 chosen from aspartic acid and glutamic acid; X15 chosen from threonine and serine; X16 chosen from arginine, alanine and lysine; X17 chosen from leucine, isoleucine and valine; X18 chosen from cysteine and methionine; preferably, the peptide CMKTDTRLC (SEQ ID No. 5).

Compounds for the diagnosis of diseases associated with VCAM expression

The invention relates to a composition comprising acid magnetic particles (p) based on an iron compound, the acid magnetic particles (p) being complexed by one or more gem-bisphosphonate compounds, of formula I:X-L-CH(POH)&#x2003;&#x2003;(I)in which:

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The invention concerns a racemic compound of the pair of enantiomers of formula (III) wherein R represents an alkyl group or a phenyl group optionally substituted.

Gadolinium complex tetramides and use in medical imaging

Metal chelates of substituted polyaminocarboxylic macrocycles and their use in diagnostic imaging

Poly(amino acid) derivatives, which are chelating agents of paramagnetic metal ions, in which at least 3 of the donor nitrogen atoms carry identical or different substituents, of formula

Polyaminated ligands and metal complexes thereof

Metal complexes of polyamino oxides, and their utilization in diagnostic

Nitrogenous macrocyclic ligands, polymetallic complexes and diagnostic

Growing community of inventors

Senlis, France

Olivier Rousseaux