Centre National De La Recherche Scientifique

Institut Gustave Roussy

Université Paris-saclay

Institut National De La Sante Et De La Recherche Medicale

Université Paris—sud

Institut National De La Sante Et De La Recherche Medicale (inserm)

Universite Paris-saclay Parc Technologique

Olivier Provot

Mouad Alami

Abdallah Hamze

Ilhem Khelifi

Jean-Daniel Brion

Samir Messaoudi

Sébastien Apcher

Romain Darrigrand

Timothée Naret

Joanna Bakala

Jérôme Bignon

Mouâd Alami

Joëlle Dubois

Jian-Miao Liu

Mohamed-Ali Soussi

Nada Makky-ibrahim

Vincent Blanchard

Anne Giraud

Jean-François Peyrat

Joanna Bakala-Wdzieczak

The present invention relates to the Compound of following formula (I): or a pharmaceutically acceptable salt thereof. The present invention also relates to a pharmaceutical composition containing such a compound and a method for preparing such a compound.

Compounds with tubulin polymerisation inhibitory activity and immunomodulatory properties

Disclosed are compounds having the formula (I): wherein Rrepresents a group: —NH, —NHCOR, —NHCOOR, —(C-C)alkenylene-CO—NH—OH, —(C-C)alkynylene-CO—NH—OH or —OH; Rrepresents a group: —OCH, —OCHCH, —SCH, —SCHCHor —OCHF; Rrepresents a hydrogen atom or a group: —CH, —CN, —F, —Cl or —OR; Rrepresents a hydrogen atom or a group: —CH, —CN, —F, —Cl or —OR; Rrepresents a group: —(C-C)alkyl or —CF; Rrepresents a group: —(C-C)alkyl or —CF; Rrepresents a group: —(C-C)alkyl or —CF; and Rrepresents a group: —(C-C)alkyl or —CF; in the state of a base or acid or acid salts or base salts or in the form of hydrate or of solvate. Also disclosed are drug conjugates including such compounds.

Drug conjugate comprising quinoline derivatives

The invention relates to compounds which are inhibitors of the polymerization of tubulin, to the methods for the production thereof, and to the uses of same.

Cytotoxic compounds which are inhibitors of the polymerisation of tubulin

The invention relates to a compound of the formula (I) in which: R, Rand Rare independently a methoxy group optionally substituted by one or more fluorine atoms; Ris a hydrogen atom; Rand Rare identical and each represent a hydrogen or fluorine atom; A is a cycle selected from the group including aryl and heteroaryl groups, wherein said groups can be substituted.

Iso CA-4 and analogues thereof as potent cytotoxic agents inhibiting tubuline polymerization

Growing community of inventors

Sartrouville, France

Olivier Provot