The Medical College of Wisconsin, Inc.

Aix-Marseille Université

Centre National De La Recherche Scientifique

Université´ D'aix-Marseille

Université De Provence

Other

Iowa State University Research Foundation, Inc.

Eth Zurich

Universite Claude Bernard – Lyon1

Bruker Biospin Gmbh

Ecole Normale Superieure De Lyon

Massachusetts Institute of Technology

Bruker France S.a.s.

Université D'aix-marseille 1

Olivier Ouari

Paul Tordo

Balaraman Kalyanaraman

Micael J Hardy

Jacek Michal Zielonka

Gang Cheng

Marcos Lopez

Melanie Rosay

Gilles Casano

Fabien Aussenac

Micael Joël Hardy

Christophe Coperet

Yoh Matsuki

Robert G Griffin

Ming You

Francois Le Moigne

Hakim Karoui

Thorsten Maly

Jean-Pierre Bernard Finet

Claire Sauvee

Anne Lesage

Neil Hogg

Florence Nathalie Laurence Chalier

Aaron Rossini

Balaraman Kalyanaramn

Lyndon Emsley

Alexandre Zagdoun

Mélanie Rosay

Christophe COPÉRET

François Le Moigne

The present invention provides mito-honokiol or mito-magnolol compounds, pharmaceutical compositions thereof, and methods of using the mito-honokiol or mito-magnolol compounds in the treatment of cancer.

Mito-honokiol compounds and methods of synthesis and use thereof

The present invention provides mito-magnolol compounds, pharmaceutical compositions thereof, and methods of using the mito-magnolol compounds in the treatment of cancer, especially anti-cancer therapy or kinase resistant cancers.

Mito-magnolol compounds and methods of synthesis and use thereof

The present invention relates to mito-lonidamine compounds, compositions and methods of use in the treatment of cancer.

Mito-lonidamine, compositions and methods of use

The present invention provides mito-metformin compounds, pharmaceutical compositions thereof, and methods of using the mito-metformin compounds in the treatment of cancer.

Modified mito-metformin compounds and methods of synthesis and use thereof

The present invention relates to a dinitroxide biradical compound of general formula (I): In formula (I), A is a carbon, an ammonium, or a phosphonium; each of A1 to A6 is a single bond, O, N, N(O), S, S(O), SO, C(O), or a (C1-C4) alkyl chain; and Z1 and Z2 are selected from R1 and R2 in combination, so that there is always at least one R2 group that is substituted with R3 group. In Z1 and Z2, R1 is an H, an aryl, or a heteroaryl; R2 is an alkyl chain, an alkenyl chain, an alkynyl chain, a cycloalkyl, a heterocycloalkyl, an aryl, or a heteroaryl; and R3 is an alkyl chain, an alkenyl chain, an alkynyl chain, a cycloalkyl, a heterocycloalkyl, an aryl, a heteroaryl, an ether, an ester, or an azide. When Z1 and Z2 are combined together with the same carbon atom of the nitroxide ring to which they are bonded, they form a spirocycloalkyl or a spiroheterocycloalkyl, the spirocycloalkyl or the spiroheterocycloalkyl being substituted with R3.

Rigid dinitroxide biradical compounds used as improved polarizing agents for dynamic nuclear polarization techniques

The invention relates to compounds of general formula (I) wherein X is C&#x2550;O or SO, M is NRor O, and Qand Qare nitroxide-containing radicals, and their use as a Dynamic Nuclear Polarization (DNP) agent for polarizing an NMR-active spin of a nucleus of an analyte in Nuclear Magnetic Resonance (NMR) spectroscopy. 

Highly efficient polarizing agents for dynamic nuclear polarization

The present invention relates to the field of organic chemistry and in particular to organic free radicals used as polarizing agents in the technique of Dynamic Nuclear Polarization (DNP), which involves transferring the polarization of electron spins to the nuclei of a compound whose Nuclear Magnetic Resonance (NMR) is being observed. It concerns dinitroxide-type biradical polarizing agents characterized by a rigid linkage between the nitroxide units that enables optimal orientation and distance to be maintained between the aminoxyl groups of said nitroxide units. This particular structure enables, at low temperatures and high fields, optimal transfer of polarization and optimal enhancement of NMR/MAS signals of the polarized nuclei of the compound studied.

Dinitroxide-type biradical compounds optimized for dynamic nuclear polarization (DNP)

Methods and compositions for detecting free radicals, the compositions being spin trapping compounds comprising a nitrone having a detecting moiety and optionally having a targeting moiety for targeting the nitrone to an organ, a cell, an organelle or a molecule of interest for directly detecting free radicals, especially free radicals in biological samples.

Bifunctional and trifunctional nitrone spin trapping compounds and uses thereof

The present invention involves new nitrons carrying a positive charge, useful in trapping of free radicals and especially the superoxide radical, of general formula: 

Nitrons carrying a positive charge and usable in trapping free radicals, especially the superoxide radical

Growing community of inventors

Seynod, France

Olivier Ouari