Centre National De La Recherche Scientifique

Université D'orleans

Jagiellonian University

Om Pharma Sa

Olivier Martin

Piotr B Heczko

Grazyna Stochel

Magdalena Strus

Cyril Nicolas

Sophie Front

Valérie Quesniaux Ryffel

Agnieszka Machul

Diana Mikolajczyk

Agnieszka Kyziol

Estelle Gallienne-Boivineau

Valerié Quesniaux Ryffel

The present invention relates to compounds of the following formula (I), wherein: m represents an integer being equal to 0, 1, 2, 3, 4, 5 or 6, X represents a simple bond or a radical &#x2014;CHRwherein Rrepresents:&#x2014;a hydrogen atom, or&#x2014;a linear or branched, possibly interrupted by up to 3 heteroatoms selected from O, S or N and/or possibly substituted, (C-C)-alkyl, R, Rand Rrepresent independently from each other:&#x2014;a hydrogen atom, or&#x2014;a linear or branched (C-C-alkyl or (C-C)-acyl R5 represents:&#x2014;a hydrogen atom, or&#x2014;a linear or branched, possibly substituted, (C-C)-alkyi possibly substituted and possibly interrupted by up to 3 heteroatoms selected from O, S or N, Rrepresents:&#x2014;a hydrogen atom, or&#x2014;a linear or branched possibly substituted (C-C)-alkyl, possibly substituted and possibly interrupted by up to 3 heteroatoms selected from O, S or N, for their use as antibacterial drugs for the treatment and/or the prevention of infection(s) caused by biofilm-forming bacteria.

Compounds for their use as drugs for the treatment and/or the prevention of infection(s) caused by biofilm-forming bacteria

The present invention relates to novel synthetic analogs of phosphatidyl-myo-inositol mannosides (hereinafter referred to as PIMs) of general formula (I): or a pharmaceutically acceptable salt thereof, to the method for preparing same and to the use thereof in the prevention or treatment of a disease associated with the overexpression of cytokines or of chemokines, in particular of TNF and/or of IL-12. The invention also relates to a pharmaceutical composition comprising at least one synthetic derivative of PIM. 

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Saint-Hilaire-Saint-Mesmin, France

Olivier Martin