Corning Incorporated

Olivier Lobet

Sylvain Maxime F Gremetz

Pierre Woehl

Roland Guidat

Elena Daniela Lavric

Alexis Maury

Stephane Poissy

Ronan Tanguy

Clemens Rudolf Horn

Thierry Luc Alain Dannoux

Dominique Roberge

Paulo Gaspar Jorge Marques

Khaled Layouni

Nikolaus H Bieler

Celine Claude Guermeur

Maxime Moreno

Paul Louis Florent Delautre

Mikhail Sergeevich Chivilikhin

Pierre Brunello

Paul Delautre

Yann P M Nedelec

Philippe J Barthe

Sylvain M Gremetz

Fouad El Jami

Aurelie Guichard

Michael Sergeevich Chivilikhin

A flow reactor has a fluidic module with a first major outer surface. The module contains a fluid passage and has a transmittance through the first major outer surface to the fluid passage of at least 20% over a range of wavelengths. The reactor has an illumination module comprising one or more radiation sources, which can emit within the range, positioned within an enclosure. The enclosure has a back wall and a side wall and an opening opposite the back wall. An edge of the side wall surrounds the opening. The illumination module is positioned such that the opening of the illumination module faces the first major outer surface of the fluidic module. The side wall comprises a telescoping portion such that a distance from the back wall of the enclosure to the edge of the side wall is adjustable.

Flow reactor for photochemical reactions

A plug () for plugging a port (P) in a flow reactor comprises a metal guide () having first and second ends () and a wall () surrounding a cylindrical interior volume () having an opening () at the first end (); a plug body () having a first face () and an opposing second face () and a side surface () and positioned partially within the interior volume () with the first face () protruding from the opening (); wherein the plug body () comprises a chemically resistant first polymer constituting at least the first face () and a thermally resistant second polymer constituting at least the second face () and at least a portion of the side surface ().

Flow reactor plug

A method of performing a reaction is disclosed comprising flowing a reaction mixture () comprising HF past a compression seal () within a flow reactor (), wherein the compression seal () includes an O-ring or gasket () and where the O-ring or gasket () comprises fluoroelastomer (to include fluoroelastomers and perfluoroelastomers), while maintaining the reaction mixture comprising HF at a temperature of 50&#xb0; C. or greater [generally at a temperature in the range of from 50&#xb0; C. and greater (60, 70, 80, 90, 100, 120, 150, and 180&#xb0; C.) up to 220&#xb0; C.], using O-rings or gaskets () that comprise a fluoroelastomer having a pre-use tensile strength in the range of from 0.1 to 14 MPa measured according to IS037, and desirably further having a compressive set in the range of from 0 to 12% measured according to IS0815.

Methods for performing flow reactions utilizing high temperature hydrofluoric acid

A flow reactor fluidic module () includes a reactant fluid module () having an internal process fluid passage () and a first major planar outer surface () and a thermal resistance R between the internal process fluid passage () and the first major planar surface (); a thermal control fluid module () having an internal thermal control fluid passage () and a second major planar outer surface (); a holding structure () holding the reactant fluid module () and the thermal control fluid module (); and a gap () separating the first major planar surface () from the second major planar surface (). The gap () comprises an interchangeable or replaceable substance or sheet () having a thermal resistance G across the gap (), wherein G is not equal to R.

Continuous flow reactor with tunable heat transfer capability

A modular photochemical reactor system having a plurality of fluidic modules each having i) a central planar process fluid layer and ii) two outer planar thermal control fluid layers for containing flowing thermal control fluid and a plurality of illumination modules, the illumination modules of the plurality each having a planar form with first and second major surfaces and each having at least a first array of semiconductor emitters, the emitters positioned to emit from or through the first major surface, wherein the first array of semiconductor emitters has at least a first emitter and a second emitter, the first emitter capable of emitting at a first center wavelength and the second emitter capable of emitting at a second center wavelength, the first and second center wavelengths differing from each other.

Modular photochemical flow reactor system

A plate-type flow reactor device with a first plate () having first and second opposing surfaces () and one or more through-holes (); a second plate sealed against the first surface () by at least two first O-rings (); a third plate () sealed against the second surface () by at least one second O-ring (); two or more first elongated channels () defined between the first surface () and the second plate and one or more second elongated channels () defined between the second surface () and the third plate, wherein each first channel communicates with the at least one second channel () via one or more of the through-holes () through the first plate (), and said one first channel () communicates with another first channel () of the two or more first channels () only via said at least one second channel (), and each first channel () is individually surrounded by at least one of the first O-rings () and the at least one second is individually surrounded by the at least one second O-ring ().

Disassemblable stacked flow reactor

A method for scale-up of a micro reactor process from lab to production scale comprises using a wall material for a lab reactor having thermal conductivity &#x2264;3 W/m&#xb7;K, and using a wall material for a production reactor having thermal conductivity &#x2265;5 W/m&#xb7;K. Desirably, flow velocity is kept constant, and the height of the production-scale process channel is determined by: wherein A B and C are constants; His the overall volumetric heat transfer coefficient, Dis the hydraulic diameter, &#x3bb;is the thermal conductivity of the wall, b is the empirically determined power to which the Reynolds number is raised in the equation for the Nusselt criteria (Nu=a&#xb7;RePr) for the type of flow used, and h is the height of the channel, all in the production-scale process; and His the overall volumetric heat transfer coefficient in the lab-scale process.

Methods for scale-up of continuous reactors

In one aspect the invention relates to reactors and a reactor system that include multiple microstructures each having a first edge and a second edge and an entrance side () and including an entrance port () and one or more other ports through the entrance side with all of the ports through the entrance side () arranged in a standard pattern and closer to the first edge than the second edge. Desirably, the entrance port () and an exit port () are concentric.

Modular reactor and system

The present disclosure provides an assembled stack of fluidic modules comprising at least first and second fluidic modules assembled in a stacked configuration. The first fluidic module has first and second major planar surfaces and encloses a first fluidic passage extending therethrough from a first passage entrance to a first passage exit with the first passage exit located on the second major planar surface of the first fluidic module. The second fluidic module also has first and second major planar surfaces and encloses a second fluidic passage extending therethrough from a second passage entrance to a second passage exit, with the second passage entrance located on the first major planar surface of the second fluidic module. The second major planar surface of the first fluidic module and the first major planar surface of the second fluidic module are spaced apart and physically joined together by at least three separate glass or glass-ceramic pads fused therebetween, and the at least three pads include at least one pad having no through-hole and at least one pad having a through-hole, with the through-hole forming a sealed fluidic interconnection between the first fluidic passage and the second fluidic passage. A method of forming the assembled stack is also disclosed.

Fluidic module permanent stack assemblies and methods

Embodiments of hybrid microfluidic assemblies comprise at least one microstructure that is formed of transparent material and is substantially free of non-transparent material and further comprise at least one microstructure that is formed of non-transparent material and is substantially free of transparent material.

Hybrid microfluidic assemblies

A modular mounting and connection or interconnection system for microfluidic devices () includes a plurality of end-butting compression-sealing fluid connectors or adapters (), and one or more clamping structures () each structured to hold one of the fluid connectors () in compression against a planar surface of a microfluidic device (), and to press against the device, on another directly opposing planar surface thereof, either a contact pad () or another of the fluid connectors (), with each clamping structure () including an individually moveable compression-providing element such as a compression screw () structured to provide a controlled amount of compression. The system desirably further includes one or more device frames () each structured so as to receive and hold a microfluidic device () with one or more of the clamping structures () attached, the device frame () being structured to retain the device () and attached clamping structures () by constraining only one or two of the clamping structures () in a manner such that no torsion or bending is applied to the device (), and one or more system frames () structured so as to receive and hold a plurality of device frames () in proximity to each other in a three-dimensional array, such that volumes of desired fluid interconnections between devices () can be minimized.

Modular mounting and connection or interconnection system for microfluidic devices

A microreactor includes a plurality of interconnected microstructures arranged in m process units with the process units configured to be operable together in parallel. Each of the m process units has a number n of respective process fluid inlets, wherein a number y of the n respective process fluid inlets are connected individually to respective non-manifolded fluid pumps, and wherein a number n minus y of the n respective process fluid inlets are connected to a respective manifolded fluid pump via a manifold, wherein y is an integer from 1 to n&#x2212;1 inclusive.

Devices and methods for microreactor fluid distribution

An end-face sealing fluidic connector for fluidic connection and/or interconnection of glass, glass-ceramic and/or ceramic fluidic modules in a microreactor includes a connector body having a circular first end face with a recess for retaining one or more O-rings and a first end section having a circular cylindrical outeT surface and a diameter In the range of from 3 to 25 mm. The outer surface has a circumferential recess dividing the first end section into a proximal portion adjacent the first end face and a distal portion. A retaining ring is seated in the circumferential recess and a protecting ring coinpming a high-compression-strength polymer surrounds the proximal portion of the first end section. A circular cylindrical sleeve surrounds the first end section and the reinforcing and/or protecting ring, the sleeve including a circumferentially extending inside bearing surface for engaging the retaining ring on the distal side thereof.

Fluid connectors for microreactor modules

A microreaction device or system () includes at least one thermal control fluidic passage (C,E) and a principal working fluidic passage (A) with average cross-sectional area in the range of 0.25 to 100 mm, and having a primary entrance () and multiple secondary entrances () with the spacing between secondary entrances () having a length along the passage (A) of at least two times the root of the average cross-sectional area of the passage (A). The device or system () also includes at least one secondary working fluidic passage (B) having an entrance () and multiple exits () including a final exit (), each exit () being in fluid communication with a corresponding one of the multiple secondary entrances () of the principal fluidic passage (A).

High throughput thermally tempered microreactor devices and methods

A microfluidic device comprises at least one reactant passage defined by walls and comprising at least one parallel multiple flow path configuration comprising a group of elementary design patterns being able to provide mixing and/or residence time which are arranged in series with fluid communication so as to constitute flow paths, and in parallel so as to constitute a multiple flow path elementary design pattern, wherein the parallel multiple flow path configuration comprises at least two communicating zones between elementary design patterns of two adjacent parallel flow paths, said communicating zones being in the same plane as that defined by said elementary design patterns between which said communicating zone is placed and allowing passage of fluid in order to minimize mass flow rate difference between adjacent parallel flow paths which have the same flow direction.

Growing community of inventors

Villiers sous Grez, France

Olivier Lobet