Proteus Digital Health, Inc.

Intrapace, Inc.

Entrack, Inc.

University of California

Vital Connect, Inc.

Otsuka Pharmaceutical Company, Limited

Olivier K Colliou

Mir A Imran

Mark Zdeblick

Ted W Layman

Sharon L Lake

Timothy Robertson

Harm TenHoff

Hooman Hafezi

Todd Thompson

Marc Jensen

Angela Strand

George M Savage

Timothy J Hughes

Deepak R Gandhi

Lawrence W Arne

Eric Snyder

Kevin Nason

Jeffrey Charles Lotz

David S Bradford

Benedict Costello

Yashar Behzadi

Robert Duck

Arshan Aga

Jeremy Frank

Robert L White

Fataneh Omidvar

Dhwanil Damania

Rod Moghadam

Behzadi Yashar

Harm Tenhoff

Georgr M Savage

Apparatuses for use with a pharmaceutically acceptable carrier. The apparatus can include a partial power source, which in turn includes electrodes or materials that are configured to generate an electrical potential upon contacting or being exposed to an ionic solution. The apparatus can further include a circuit electrically or communicatively coupled to the partial power source. The circuit can generate various types of signals, such as RF signals, when powered by the partial power source. The circuit is stably fittable to the pharmaceutically acceptable carrier. The apparatus can further include a barrier, a protective layer, or a membrane that isolates the electrodes or materials from the ionic solution and is configured to be dissolved by the ionic solution.

Controlled activation ingestible identifier

A device-securing overlay includes a wearable strip that has a controlled applicant to fit over at least a portion of a wearable device, while an adhesive on an under portion of the wearable strip is placed in contact with at least a top portion of an outer rim of the wearable device as well as a surface upon which the wearable device is placed, without covering portions of the wearable device that require ventilation or an unobstructed view.

Adhesive overlay

A system and method for detecting and monitoring core body temperature are disclosed. The system includes a patch device and an electronic module coupled to the patch device. The method includes providing a patch device, coupling an electronic module to the patch device to provide a wearable device, and monitoring core body temperature of a user using the wearable device.

Core body temperature detection device

Low profile antennas for ingestible devices, such as ingestible event markers, are provided. Aspects of the ingestible devices of the invention include low profile signal transmission antennas configured such that they are flexible or degrade after use, allowing the antenna and attached components to pass easily through the body. Embodiments of the low profile antennas are configured to emit a detectable signal upon contact with a target physiological site. Also provided are methods of making and using the devices of the invention.

Low profile antenna for in body device

Controlled activation identifiers for use in ingestible compositions, such as pharma-informatics enabled compositions, are provided. The identifiers include a controlled activation element that provides for activation of the identifier in response to the presence of a predetermined stimulus at a target site of interest. The invention finds use in a variety of different applications, including but not limited to, monitoring of therapeutic regimen compliance, tracking the history of pharmaceutical agents, etc.

A device, system and method for diagnosing and treating gastric disorders is provided. A submucosal gastric implant device is placed within the submucosal layer of a patient's stomach wall. The device in one embodiment provides electrical stimulation of the stomach wall and may use multiple electrode pairs for sequential stimulation. The device may also have other functional aspects such as a sensor for sensing various parameters of the stomach or stomach environment, or a therapeutic delivery device. The implant may be programmed to respond to sensed information or signals. The device may be modular with a portion of the device accessible outside the stomach wall for removal and replacement. An endoscopic delivery system prepares and delivers the functional device through the esophagus and into the stomach where it is placed through an opening in the mucosa into the submucosal layer of the stomach wall. The endoscopic instruments may be used to prepare a cavity in the submucosal layer of the stomach wall and deliver the device to the prepared cavity and if appropriate close the opening in the mucosa.

Submucosal gastric implant device and method

A device and method for mapping, diagnosing and treating the intestinal tract is provided using a capsule passing through the intestinal tract. Further, a capsule tracking system is provided for tracking a capsule's location along the length of an intestinal tract as various treatment and/or sensing modalities are employed. In one variation, an acoustic signal is used to determine the location of the capsule. A map of sensed information may be derived from the pass of a capsule. Capsules may be subsequently passed through to treat the intestinal tract at a determined location along its length. One variation uses an electrical stimulation capsule to treat and/or diagnose a condition in the intestinal tract.

System for marking a location for treatment within the gastrointestinal tract

A body associated device comprises a housing, an adhesive layer configured to be applied to a body of a living subject, and at least one standoff located between the housing and the adhesive layer. An electronic module may be located within the housing of the body associated device. A personal communication system comprises a body associated device including an electronic module and further comprises a feedback portion coupled to the housing and to the electronic module. The feedback portion is configured to communicate information between the living subject and the body associated device. An external local node is operative to provide at least one of transmit communications to and receive communications from the body associated device.

Wearable personal body associated device with various physical configurations

Multi-directional transmitters for in-body devices, such as implantable and ingestible devices, are provided. Aspects of the in-body multi-direction transmitters of the invention include signal transmitters configured to transmit an identifying signal in at least two different directions in an x-y plane. Embodiments of the in-body devices are configured to emit a detectable signal upon contact with a target physiological site. Also provided are methods of making and using the devices of the invention.

In-body device having a multi-directional transmitter

Implantable stimulation devices are provided. Aspects of the devices include a multiplexed multi-electrode component configured for neural stimulation. The multiplexed multi-electrode component includes two or more individually addressable satellite electrode structures electrically coupled to a common conductor. The satellite structures include a hermetically sealed integrated circuit controller operatively coupled to one or more electrodes. Also provided are systems that include the devices of the invention, as well as methods of using the systems and devices in a variety of different applications.

Multiplexed multi-electrode neurostimulation devices

Portable electroviscerography systems are provided. Aspects of the systems include a body-associated receiver and an ingestible identifier unit, both of which are configured to detect visceral electrical signals. The system communicates with an extra-corporeal data processor configured to receive data from the body-associated receiver and generate and electroviscerogram from the received data. Also provided are methods of producing electroviscerograms using systems of the present invention.

Evaluation of gastrointestinal function using portable electroviscerography systems and methods of using the same

Growing community of inventors

Menlo Park, CA, United States of America

Olivier K Colliou