Centre Hospitalier Universitaire Vaudois

Centre National De La Recherche Scientifique

Universite Claude Bernard – Lyon1

Antia Therapeutics S.a.

Universitè De Genève

University of Geneva

Université De Genve

Centre Hospitaller Universitaire Vaudois (Chuv)

Olivier Jordan

Eric Doelker

Yves Chevalier

Géraldine Agusti

Alban Denys

Gert Andersen

Coralie Nyffenegger

Pierre Bize

Nathalie Boulens

Robert Gurny

Jean-Louis Reymond

Eric Allemann

Florence Delie

Ludmila Luca

Viorica Patrulea

Bee Ha Gan

Pierre Maudens

Jacques-Antoine Haefliger

Gerrit Borchard

François Saucy

Ioanna Mylonaki

Sema Gwendolyn Kaderli

Geraldine Agusti

The invention relates to a bio-conjugate comprising a chitosan derivative coupled to an antimicrobial peptide (AMP) for use in the treatment or prevention of a microbial infection, for example in wound healing. The invention also provides a nanoparticle formulation or a gel/hydrogel formulation or a lyophilized foam formulation comprising the bio-conjugate of the invention.

Antimicrobial tailored chitosan

The present invention is directed to new graft polymer of a hyaluronic acid polymer and N-isopropylacrylamide based polymer, preparations, compositions and uses thereof. In particular, the invention relates to pH and/or thermo-sensitive compositions able to form spontaneously nanoparticles useful as active and agents and delivery systems for at least one bioactive agent.

Hyaluronic acid conjugates and uses thereof

The invention relates to chemoembolization compositions for anti-angiogenic agent delivery. The invention further relates to a method of preparing chemoembolization compositions and to the use of chemoembolization compositions in the method for treating solid tumour cancers.

Chemoembolization composition comprising anti-angiogenic agents

The present invention relates generally to a pharmaceutical formulation for use in the treatment and/or prevention of restenosis in a subject in need thereof. Methods of treatment and/or prevention are also provided.

Pharmaceutical formulation for use in the treatment and/or prevention of restenosis

The invention relates to chemoembolization composition for anti-angiogenic agent delivery. The invention further relates to a method of preparing chemoembolization composition and to the use of chemoembolization composition in the method for treating solid tumor cancers.

The present invention relates to compositions and pharmaceutical compositions having a hyaluronic acid; a chitosan; and at least one ionic compound in hydrogel form, their use in medical applications and methods of making same as well as medical devices comprising same.

Hybrid hydrogels

A method of embolizing an area of treatment includes providing a composition that includes a radiopaque, non-biodegradable, water-insoluble iodinated benzyl ether of poly(vinyl alcohol) consisting of a poly(vinyl alcohol) (PVA) having covalently grafted thereon iodinated benzyl groups comprising from 1 to 4 iodine atoms per benzyl group as the only substituents wherein a grafted repeating unit has formula (I) wherein n is from 1 to 4: and introducing the composition into the area of treatment.

Method of embolization using a radiopaque, non-biodegradable, water-insoluble iodinated benzyl ether of polyl(vinyl alcohol)

The invention concerns a radiopaque, non-biodegradable, water-insoluble iodinated benzyl ether of poly(vinyl alcohol) consisting of a PVA having covalently grafted thereon iodinated benzyl groups comprising 1-4 iodine atoms per benzyl group, a process for preparing the same comprising reacting a 0-100% hydrolyzed PVA with a iodinated benzyl derivative comprising 1-4 iodine atoms per benzyl group in a polar aprotic solvent in the presence of a base in anhydrous conditions. Said iodo-benzylether-PVA is particularly useful as embolic agent in an injectable embolizing composition. The invention also concerns an injectable embolizing composition comprising said iodo-benzylether-PVA and capable of forming a cohesive mass upon contact with a body fluid by precipitation of the iodo-benzylether-PVA. Said injectable embolizing composition is particularly useful for forming in-situ a cohesive mass in a blood vessel or into a tumor. The invention further concerns a coating composition containing said iodo-benzylether-PVA and capable of forming a radiopaque coating on a medical device. The invention further concerns particles formed of said iodo-benzylether-PVA.

Radiopaque, non-biodegradable, water-insoluble iodinated benzyl ethers of poly(vinyl alcohol), preparation method thereof, injectable embolizing compositions containing thereof and use thereof

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Prangins, Switzerland

Olivier Jordan